benson lab
Cellular Mechanisms of Circuit Formation, Activity, & Behavior
Hsiao K, Bozdagi O, Benson DL. (2014) Axonal cap-dependent translation regulates presynaptic p35. Dev Neurobiol. Mar;74 (3):351-64.



  Matikainen-Ankney BA*, Kezunovic N*, Mesias RE, Tian Y, Williams FM, +Huntley GW, +Benson DL (2016) Altered development of synapse structure and function in striatum caused by Parkinson's disease-linked LRRK2-G2019S mutation. Journal of Neuroscience, in press.
  *Hsiao K, Harony-Nicolas H, Buxbaum JD, +Bozdagi-Gunal O, +Benson DL. (2016) Cyfip1 regulates presynaptic activity during development. J. Neuroscience 36:1564-76.
  Carcea I, Benson DL. (2016) Visualizing and characterizing Semaphorin endocytic events using quantum dot conjugated proteins. Methods in Molecular Biology, in "Semaphorin Signaling: Methods and Protocols. Vol 1493. Editor Jonathan R Terman.


  Friedman LG, Riemslagh FW, Sullivan JM, Mesias R, Williams FM, Huntley GW, Benson DL. (2015) Cadherin-8 expression, synaptic localization and molecular control of neuronal form in prefrontal cortico-striatal circuits. Journal of Comparative Neurology, 523:75-92. PMID 25158904
  Friedman LG, Benson DL, Huntley GW. (2015) Cadherin-based transsynaptic networks in establishing and modifying neural connectivity. Current Topics in Devopmental Biology:112:415-65.


  Carcea I, Patil SB, Robison, AJ, Mesias R, Huntsman MM, Froemke RC, Buxbaum JD, Huntley GW, Benson DL (2014) Maturation of cortical circuits requires Sema7A. Proc Natl Acad Sci, USA 111: 13978-83.
  Kinoshita Y, Hunter RG, Gray JD, Mesias R, McEwen BS, Benson DL, Kohtz DS. Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress. (2014) Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16130-5
  Nikitczuk JS, Patil SB, Matikainen-Ankney BA, Scarpa J, Shapiro ML, Benson DL, Huntley GW. Hippocampus. (2014) N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Aug;24(8):943-62
  Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. (2014) The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J. May;28(5):2120-33



Mintz CD, Barrett KMS, Benson DL, Harrison NL. Anesthetics interfere with axon guidance in developing mouse neocortical neurons via a GABAA receptor mechanism. Anesthesiology, 118: 825-833, 2013.

  Sepulveda B, Mesias R, Li X, Yue Z, Benson DL, Short- and long-term effects of LRRK2 on axon and dendrite growth, PLoS One 8: e61986, 2013.
  Davies P, Hinkle KM, Sukar N, Sepulveda B, Mesias R, Serrano G, Alessi D, Beach TG, Benson DL, White CL, Cowell R, Das SS, West AB, Melrose HL. A comprehensive evaluation of Leucine Rich Repeat Kinase 2 monoclonal antibodies in rodent and human brain, Biochemical Journal 453: 101-13, 2013.


Mortillo S, Elste AM, Ge Y., Patil SB, Hsiao K, Huntley GW, Davis RL, Benson DL. Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic ß1-integrin. Journal of Comparative Neurology, 520: 2041-52, 2012.

Benson DL and Huntley GW. Synapse adhesion: a dynamic equilibrium conferring stability and flexibility, Current Opinion in Neurobiology, 22: 397-404, 2012.


Mintz CD, Smith SC, Barrett KMS, Harrison, NL, Benson, DL. Anesthetics interfere with the polarization of developing cortical neurons, Journal of Neurological Anesthesia, 4: 368 - 375, 2012.

  Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, Gonzalez-Maeso J. Identification of three residues essential for 5-Hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A-mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287: 44301-19, 2012.


Sepulveda B., Carcea I, Zhao B, Salton SRJ, Benson DL. L1CAM promotes resistance to alcohol-induced silencing of growth cone responses to guidance cues, Neuroscience 180: 30-40, 2011. 57.

Huntley GW, Elste AM, Patil SB, Bozdagi O., Benson DL and Steward O. Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo. Hippocampus 22, 17 - 28, 2012.

Benson, D.L and Huntley, G.W. Building and remodeling synapses. Hippocampus, 22: 954-968, 2011.


Carcea I, Ma'ayan A, Mesias R, Sepulveda B, Salton SR, Benson DL.  Flotillin-mediated endocytic events dictate cell-type specific responses to Semaphorin 3A, Journal of Neuroscience 30:15317-15329, 2010.

*Bozdagi, O, *Wang, X, *Nikitczuk, J.S., Anderson, T.R., Bloss, E.G. Radice, G.L., Zhou, Q, +Benson, D.L., +Huntley, G. W. Persistence of coordinated LTP and dendritic spine enlargement at mature synapses requires N-cadherin, Journal of Neuroscience, 30:9984-9989, 2010.

Huntley, G.W., Elste, A.M., Patil, S.B., Bozdagi, O., Benson, D.L. and Steward, O. (2010) Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo. Hippocampus (ePub ahead of print).

Benson, D.L and Huntley, G.W. Building and remodeling synapses. Hippocampus, 2010, (ePub ahead of print).


Bekirov, I. H., Nagy, V., Svoronos, A., Huntley, G. W., Benson, D. L., Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway. Hippocampus 18(4) 349-63, 2008.

*Mintz, C. D., *Carcea, I, McNickle, D. G., Dickson, T.C., Ge, Y., Salton, S. R. J., Benson, D. L.  ERM proteins regulate growth cone responses to Sema3A, Journal of Comparative Neurology 510(4):351-66, 2008.

Sakurai, T., Gil, O. D., Whittard, J. D., Gazdoiu, M., Joseph, T., Wu, J., Waksman, A., Benson, D. L., Salton, S. R., Felsenfeld, D. P. Interactions between L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation. J Neuroscience Research 86(12):2602-14, 2008.

Hoffman E.J., Mintz, C. D., Wang, S., McNickle, D.G., Salton, S.R.J., Benson, D.L. Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons.  Neuroscience 157(3):556-65, 2008.


Sebeo, J Benson, D. L. Restabilizing a retrieved memory: the role of protein degradation. Cell Science Reviews 4 (4) 25-30, 2008.


Akins, M. R., Benson, D. L., Greer, C. A. Cadherin expression in the developing mouse olfactory system. Journal of Comparative Neurology 501(4):483-97, 2007.


Zhang, W. and Benson, D. L.  Targeting and clustering citron to synapses. Molecular and Cellular Neuroscience 31: 26-36, 2006.

Elste, A.M. and Benson, D. L. Structural basis for developmentally regulated changes in cadherin function at synapses. Journal of Comparative Neurology 495(3):324-35, 2006.

Elste, A.M. and Benson, D. L. Structural basis for developmentally regulated changes in cadherin function at synapses. Journal of Comparative Neurology 495(3):324-35, 2006.

Mintz, C. D., Bekirov, I. H., *Anderson, T. R. and Benson, D. L., Neuronal Differentiation:  From Axons to Synapses. In: Brain Development: Normal Processes and the Effects of Alcohol and Nicotine. Ed. Miller, M. W., Oxford University Press, 2006, pp 45-72.


Anderson, T. R. and Benson, D. L.  Cadherin-mediated adhesion and signaling during vertebrate central synapse formation. In:  Molecular Mechanisms of Synaptogenesis. Ed. A. Dityatev and A. El-Husseini. Springer Press, 2006, pp 83-110.



Garcia, A.L., Han, S.K. Khaing, Z. Z., Ito, T. Glucksman, M. J., Benson, D. L., Salton, S. R. J. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.Journal of  Biological Chemistry, 280:41595-608, 2005.


Bozdagi, O., Valcin, M., Poskanzer, K., Tanaka, H, and Benson, D. L. Temporally distinct demands for classic cadherins in synapse formation and maturation.  Molecular and Cellular Neuroscience, 27:509-521, 2004.

Anderson, T. A., Shah, P. A., Benson, D. L., Maturation of glutamatergic and GABAergic synapse composition in hippocampal neurons.  Neuropharmacology, 47: 694-705, 2004



Phillips, GR, Tanaka, H, Frank, M, Elste, A, Fidler, L, Benson, DL, Colman, DR. Gamma-protocadherins are targeted to subsets of synapses and intracellular organelles in neurons. Journal of Neuroscience, 23, 5096-5104, 2003.


Mintz, C. D., Dickson, T. C., Gripp, M. L., Salton, S. R. J. and Benson, ERMs colocalize transiently with L1 during neocortical axon outgrowth. Journal of Comparative Neurology,464, 438-448, 2003.



Bekirov, I.H., Needleman, L. A., Zhang, W. and Benson, D. L. Developmental regulation and circuit specific distribution of classic cadherins in the rat limbic system.  Neuroscience, 115: 213-227 2002.


Dickson, T.L., +Benson, D.L. and +Salton, S.R.J. Functional binding interaction identified between the axonal CAM L1 and members of the ERM family. J. Cell Biology 157, 1105-1112, 2002.+ equal contributions.

Gazzaley, A., Kay, S. and Benson, D. L. Dendritic spine plasticity in hippocampus. Neuroscience 111, 853-862, 2002.

  Huntley, G. W., Benson, D.L. and Colman, D. R. Structural remodeling of the synapse in response to physiological activity. Cell,108, 1-4, 2002


Zhang, W. and D. L. Benson  Two stages of synaptogenesis defined by F-actin. Journal of Neuroscience, 21, 5169-5181, 2001.


Benson, D. L., Colman, D.R. and Huntley, G. W. Molecules, maps and synapse specificity. Nature Reviews Neuroscience, 2, 899-909, 2001.



Tanaka, H., Shan, W-S., Phillips, G. R., Arndt, K., Huntley, G. W., Bozdagi, O., Shapiro, L., Benson,  D.L. and Colman, D. R. (2000) Molecular modification of N-cadherin in response to synaptic stimulation. Neuron 25:93-107, 2000.(journal cover)


Bozdagi, O., Shan, W., Tanaka, H., +Benson, D. L. +Huntley, G. W. Increasing numbers of synaptic puncta during late-phase LTP: N - cadherin is synthesized, recruited to synaptic sites, and required for potentiation. Neuron 28, 245-258, 2000. +equal contributions

Zhang, W. and Benson, D. L.  Development and molecular organization of dendritic spines and their synapses Hippocampus, editors K. Sorra and K. Harris. 10, 512-526, 2000.

Benson, D. L., Schnapp, L., Shapiro, L. and Huntley, G.W. Making memories stick:  cell adhesion and synapse plasticity.  Trends in Cell Biology 10, 473-482, 2000