neuro
casaccia lab
epigenetics of neural repair

PUBLICATIONS

2017

Motl RW, Mowry EM, Ehde DM, LaRocca NG, Smith KE, Costello K, Shinto L, Ng AV, Sullivan AB, Giesser B, McCully KK, Fernhall B, Bishop M, Plow M, Casaccia P, Chiaravalloti ND. Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Mult Scler. 2017 Jan 1:1352458516687404. doi: 10.1177/1352458516687404. [Epub ahead of print] PubMed PMID: 28080254.
  Dickens, AM., Tovar-y-Romo, LB.,Yoo, SW., Trout, AL., Bae, M., Kanmogne, M., Megra, B., Williams, DW., Witwer, K., Gacias, M., Tabatadze, N., Cole, R., Casaccia, P., Berman, JW., Anthony, DC., Haughey, N. (2016). Astrocyte-Shed extracellular vesicles regulate the leukocyte response to inflammatory brain lesions. Science Signaling (In press).
  Moyon, S, Ma D, Huynh JL, Coutts DJC, Zhao C, Casaccia P. and Franklin RJM (2017). Efficient remyelination requires DNA methylation. eNeuro (in press)
  Moyon, S. Casaccia P (2017). DNA methylation in oligodendroglial cells during developmental myelination and in disease. Neurogenesis (in press)

2016

Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJ, Fan G, Zhu J, Dupree JL, Casaccia P. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep. 2016 Apr 13. pii: S2211-1247(16)30331-X. doi: 10.1016/j.celrep.2016.03.060. [Epub ahead of print] PubMed PMID: 27149841; PubMed Central PMCID: PMC5063656.
Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, Haroutunian V, Zhang B. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease. Genome Med. 2016 Nov 1;8(1):104. PubMed PMID: 27799057; PubMed Central PMCID: PMC5088659.
Liu J, Moyon S, Hernandez M, Casaccia P. Epigenetic control of oligodendrocyte development: adding new players to old keepers. Curr Opin Neurobiol. 2016 Aug;39:133-8. doi: 10.1016/j.conb.2016.06.002. Review. PubMed PMID: 27308779; PubMed Central PMCID: PMC4987162.
Ntranos A, Casaccia P. Bromodomains: Translating the words of lysine acetylation into myelin injury and repair. Neurosci Lett. 2016 Jun 20;625:4-10. doi: 10.1016/j.neulet.2015.10.015. Review. PubMed PMID: 26472704; PubMed Central PMCID: PMC4841751.
Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer EG, Mitiku N, Loo H, Burlant N, Pedre X, Hara Y, Nudelman G, Zaslavsky E, Lee YM, Braun DA, Lu QR, Narla G, Raine CS, Friedman SL, Casaccia P, John GR. The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination. PLoS Biol. 2016 May 23;14(5):e1002467. doi: 10.1371/journal.pbio.1002467. PubMed PMID: 27213272; PubMed Central PMCID: PMC4877075.
Moyon S, Liang J, Casaccia P. Epigenetics in NG2 glia cells. Brain Res. 2016 May 1;1638(Pt B):183-98. doi: 10.1016/j.brainres.2015.06.009. Review. PubMed PMID: 26092401; PubMed Central PMCID: PMC4683112.
Douvaras P, Rusielewicz T, Kim KH, Haines JD, Casaccia P, Fossati V. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. Int J Mol Sci. 2016 Apr 22;17(4). pii: E614. doi: 10.3390/ijms17040614. PubMed PMID: 27110779; PubMed Central PMCID: PMC4849063.
Gacias M, Gaspari S, Santos PM, Tamburini S, Andrade M, Zhang F, Shen N, Tolstikov V, Kiebish MA, Dupree JL, Zachariou V, Clemente JC, Casaccia P. Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior. Elife. 2016 Apr 20;5. pii: e13442. doi: 10.7554/eLife.13442. PubMed PMID: 27097105; PubMed Central PMCID: PMC4880443.
Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJ, Fan G, Zhu J, Dupree JL, Casaccia P. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep. 2016 Apr 13. pii: S2211-1247(16)30331-X. doi: 10.1016/j.celrep.2016.03.060. [Epub ahead of print] PubMed PMID: 27149841; PubMed Central PMCID: PMC5063656.
Liu J, Dupree JL, Gacias M, Frawley R, Sikder T, Naik P, Casaccia P. Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. J Neurosci. 2016 Jan 20;36(3):957-62. doi: 10.1523/JNEUROSCI.3608-15.2016. PubMed PMID: 26791223; PubMed Central PMCID: PMC4719024.
Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. J Neurosci. 2016 Jan 20;36(3):806-13. doi: 10.1523/JNEUROSCI.2873-15.2016. PubMed PMID: 26791211; PubMed Central PMCID: PMC4719016.

2015

Zhao, C., Ma, D., Zawadzka, M., Fancy,S., Elis-Williams,L., Bouvier, G., Stockley, J., De Castro, G., Wang,B., Jacobs,S., Casaccia, P, Robin, F. (2015). Sox2 sustains recruitment of oligodendrocyte progenitor cells following CNS demyelination and primes them for differentiation during CNS remyelination. J Neurosci 2015. Aug 19;35(33):11482-99. doi: 10.1523/JNEUROSCI.3655-14.2015.
Rolyan,H., Tyurina,Y., Hernandez, M., Amoscato, A., Sparvero,L., Nmezi, B., Lu, Y., Estécio, M., Lin,K., Chen, J., He,R., Gong,P., Rigatti, L., Jeffery, D., Bayır, H., Kagan, V., Casaccia, P., Padiath, Q. (2015).Defects of lipid synthesis are linked to the age dependent demyelination caused by Lamin B1 over expression. J Neurosci 2015. PMID: 26311780 [PubMed - in process] PMCID: PMC4549407.
Multiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors. Haines JD, Vidaurre OG, Zhang F, Riffo-Campos ÁL, Castillo J, Casanova B, Casaccia P, Lopez-Rodas G.Mult Scler. 2015 May 6. pii: 1352458515573094. [Epub ahead of print]PMID: 25948622.
Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage.Hernandez M, Casaccia P.Glia. 2015 May 12. doi: 10.1002/glia.22818. [Epub ahead of print] PMID:25970296.
Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Feng J, Shao N, Szulwach KE, Vialou V, Huynh J, Zhong C, Le T, Ferguson D, Cahill ME, Li Y, Koo JW, Ribeiro E, Labonte B, Laitman BM, Estey D, Stockman V, Kennedy P, Couroussé T, Mensah I, Turecki G, Faull KF, Ming GL, Song H, Fan G, Casaccia P, Shen L, Jin P, Nestler EJ.Nat Neurosci. 2015 Apr;18(4):536-44. doi: 10.1038/nn.3976. Epub 2015 Mar 16.PMID:25774451.
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.Haines JD, Herbin O, de la Hera B, Vidaurre OG, Moy GA, Sun Q, Fung HY, Albrecht S, Alexandropoulos K, McCauley D, Chook YM, Kuhlmann T, Kidd GJ, Shacham S, Casaccia P.Nat Neurosci. 2015 Apr;18(4):511-20. doi: 10.1038/nn.3953. Epub 2015 Feb 23.PMID:25706475.
Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.Liu J, Magri L, Zhang F, Marsh NO, Albrecht S, Huynh JL, Kaur J, Kuhlmann T, Zhang W, Slesinger PA, Casaccia P.J Neurosci. 2015 Jan 7;35(1):352-65. doi: 10.1523/JNEUROSCI.2606-14.2015.PMID: 25568127.

2014

 

Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J.,Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. Mol Syst Biol. 2014 Jul 30;10(7):743. doi: 10.15252/msb.20145304. PMID:25080494.

 

Gacias M, Gerona-Navarro G, Plotnikov AN, Zhang G, Zeng L, Kaur J, Moy G, Rusinova E, Rodriguez Y, Matikainen B, Vincek A, Joshua J, Casaccia P, Zhou MM. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol. 2014 Jul 17;21(7):841-54. doi: 10.1016/j.chembiol.2014.05.009. Epub 2014 Jun 19. PMID:24954007.

 

Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR. Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28. doi: 10.1242/dev.106492. PMID:24917498.

 

Vidaurre OG, Haines JD, Katz Sand I, Adula KP, Huynh JL, McGraw CA, Zhang F, Varghese M, Sotirchos E, Bhargava P, Bandaru VV, Pasinetti G, Zhang W, Inglese M, Calabresi PA, Wu G, Miller AE, Haughey NJ, Lublin FD, Casaccia P. Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics. Brain. 2014 Aug;137(Pt 8):2271-86. doi: 10.1093/brain/awu139. Epub 2014 Jun 3. PMID:24893707.

 

Magri L, Gacias M, Wu M, Swiss VA, Janssen WG, Casaccia P. c-Myc-dependent transcriptional regulation of cell cycle and nucleosomal histones during oligodendrocyte differentiation. Neuroscience. 2014 Sep 12;276:72-86. doi: 10.1016/j.neuroscience.2014.01.051. Epub 2014 Feb 4. PMID: 24502923.

 

Magri L, Swiss VA, Jablonska B, Lei L, Pedre X, Walsh M, Zhang W, Gallo V, Canoll P, Casaccia P., E2F1 coregulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation.J Neurosci. 2014 Jan 22;34(4):1481-93. doi: 10.1523/JNEUROSCI.2840-13.2014. PMID:24453336.

2013

Gacias M, Casaccia P. Promoting return of function in multiple sclerosis: An integrated approach. Mult Scler Relat Disord. 2013 Oct 1;2(4). doi: 10.1016/j.msard.2013.04.002. PubMed PMID: 24363985; PubMed Central PMCID: PMC3868478.

Huynh JL, Casaccia P. Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol. 2013 Feb;12(2):195-206. doi: 10.1016/S1474-4422(12)70309-5. Review. PubMed PMID:23332363; PubMed Central PMCID: PMC3690378.

Bharadwaj R, Jiang Y, Mao W, Jakovcevski M, Dincer A, Krueger W, Garbett K, Whittle C, Tushir JS, Liu J, Sequeira A, Vawter MP, Gardner PD, Casaccia P, Rasmussen T, Bunney WE Jr, Mirnics K, Futai K, Akbarian S. Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia. J Neurosci. 2013 Jul 17;33(29):11839-51. doi: 10.1523/JNEUROSCI.1252-13.2013.
PubMed PMID: 23864674; PubMed Central PMCID: PMC3713726.
Huynh JL, Garg P, Thin TH, Yoo S, Dutta R, Trapp BD, Haroutunian V, Zhu J, Donovan MJ, Sharp AJ, Casaccia P. Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci. 2013 Nov 24. doi: 10.1038/nn.3588. [Epub ahead of print] PubMed PMID: 24270187.
Magri. L., Swiss VA, Jablonska B., Lei, L., Pedre X., Walsh, M., w. Zhang., Gallo V., Canoll, P., Casaccia P. E2F1 co-regulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation. J. Neurosci , in press.

2012

Liu J, Dietz K, Deloyht JM, Pedre X, Kelkar D, Kaur J, Vialou V, Lobo MK, Dietz DM, Nestler EJ, Dupree J, Casaccia P. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci. 2012 Nov;15(12):1621-3. doi: 10.1038/nn.3263. Epub 2012 Nov 11. PubMed PMID: 23143512; PubMed Central PMCID: PMC3729624. Press release.

Vidaurre OG, Liu J, Haines J, Sandoval J, Nowakowski R, Casaccia P. An integrated approach to design novel therapeutic interventions for demyelinating disorders. Eur J Neurosci. 2012 Jun;35(12):1879-86. doi: 10.1111/j.1460-9568.2012.08118.x. Review.

Wu M, Hernandez M, Shen S, Sabo JK, Kelkar D, Wang J, O'Leary R, Phillips GR, Cate HS,Casaccia P. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. J Neurosci. 2012 May 9;32(19):6651-64. doi: 10.1523/JNEUROSCI.4876-11.2012.

2011

Gil-Perotin S, Haines JD, Kaur J, Marin-Husstege M, Spinetta MJ, Kim KH, Duran-Moreno M, Schallert T, Zindy F, Roussel MF, Garcia-Verdugo JM, Casaccia P. Roles of p53 and p27(Kip1) in the regulation of neurogenesis in the murine adult subventricular zone. Eur J Neurosci. 2011 Oct;34(7):1040-52. doi: 10.1111/j.1460-9568.2011.07836.x. Epub 2011 Sep 7.
DiNieri JA, Wang X, Szutorisz H, Spano SM, Kaur J, Casaccia P, Dow-Edwards D, Hurd YL. Maternal cannabis use alters ventral striatal dopamine D2 gene regulation in the offspring. Biol Psychiatry. 2011 Oct 15;70(8):763-9. doi: 10.1016/j.biopsych.2011.06.027. Epub 2011 Aug 5.
Casaccia P. Anti-TANKyrase weapons promote myelination. Nat Neurosci. 2011 Jul 26;14(8):945-7. doi: 10.1038/nn.2885. No abstract available.
 

Swiss VA, Nguyen T, Dugas J, Ibrahim A, Barres B, Androulakis IP, Casaccia P. Identification of a gene regulatory network necessary for the initiation of oligodendrocyte differentiation. PLoS One. 2011 Apr 7;6(4):e18088.

Inglese M, Oesingmann N, Casaccia P, Fleysher L. Progressive multiple sclerosis and gray matter pathology: an MRI perspective.
Mt Sinai J Med. 2011 Mar-Apr;78(2):258-67. doi: 10.1002/msj.20247. Review.

Haines JD, Inglese M, Casaccia P. Axonal damage in multiple sclerosis. Mt Sinai J Med. 2011 Mar-Apr;78(2):231-43. doi: 10.1002/msj.20246.
Pedre X, Mastronardi F, Bruck W, Lopez-Rodas G, Kuhlmann T, Casaccia P. Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. J Neurosci. 2011 Mar 2;31(9):3435-45. Erratum in: J Neurosci. 2011 Jun 1;31(22):8325.

2010

He Y, Kim JY, Dupree J, Tewari A, Melendez-Vasquez C, Svaren J, Casaccia P. Yy1: a molecular link between neuregulin and transcriptional modulation of peripheral myelination. Nature Neurosci 2010 13(12): 1472-1480 (see attached pdf).

Liu J, Casaccia P. Epigenetic regulation of oligodendrocyte identity [review]. Trends Neurosci 2010 Apr; 33(4): 193-201.

Kim JY, Shen S, Dietz K, He Y, Howell O, Reynolds R, Casaccia P. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nature Neurosci 2010 Feb; 13(2): 180-189. (see attached pdf and news and views)

 

Liu J, Sandoval J, Lopez-Rodas G, Doh S, Cai L, Casaccia P. Epigenetic Modifiers Are Necessary but Not Sufficient for Reprogramming Non-Myelinating cells into Myelin Gene-expressing Cells. PlosONE 2010; 5:  1303.

Mattan NS, Ghiani CA, Lloyd M, Matalon R, Bok D, Casaccia P, de Vellis J. J.Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination . Neurobiol Dis 2010 Jul; 40:432-433.

Kim JY, Casaccia P. (2010) HDAC1 in axonal degeneration : a matter of subcellular localization. Cell Cycle, 2010 9 (18): 3680-3684.

Yu Y, Casaccia P, Lu QR. Shaping the oligodendrocyte identity by epigenetic control. Epigenetics. 2010 Feb 16;5(2):124-8. Review. PubMedPMID: 20160514.

 

Dietz KC, Casaccia P. HDAC inhibitors and neurodegeneration: at the edge between protection and damage. Pharmacol Res. 2010 Jul;62(1):11-7. Review. PubMed PMID: 20123018

Germano I, Swiss V, Casaccia P. Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link? Neuropharmacology. 2010May;58(6):903-10. Review. PubMed PMID: 20045420

Swiss VA, Casaccia P. Cell-context specific role of the E2F/Rb pathway in development and disease. Glia. 2010 Mar;58(4):3. Review

Kerns D, Vong GS, Barley K, Dracheva S, Katsel P, Casaccia P, Haroutunian V, Byne W. Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia. Schizophr Res. 2010 Jul;120(1-3):150-8.. PubMed PMID: 20580881.

2009

Copray, S., Huynh, J.L., Sher, F., Casaccia-Bonnefil, P., and Boddeke, E. (2009). Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging. Glia 57 (15): 1579-1587

Kim JY, Casaccia-Bonnefil P. Interplay of hormones and p53 in modulating gender dimorphism of subventricular zone cell number. J Neurosci Res. 2009 Nov 15;87(15):3297-305. PubMed PMID: 19025772

Huynh,JL, Casaccia P. Defining the chromatin landscape in demyelinating disorders. Neurobiol Dis. 2010 Jul;39(1):47-52. Review PubMed PMID:19853663.

2008

Shen, S., Sandoval, J., Swiss, V.A., Li, J., Dupree, J., Franklin, R.J., and Casaccia-Bonnefil, P. (2008). Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci. Read the news from Nature and Nature Neuroscience (see attached pdf and news and views)

Casaccia-Bonnefil, P., Pandozy, G., and Mastronardi, F. (2008). Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol 86, 368-378.

Li, J., Ghiani, C.A., Kim, J.Y., Liu, A., Sandoval, J., DeVellis, J., and Casaccia-Bonnefil, P. (2008). Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination. J Neurosci 28, 6118-6127.

He, Y., and Casaccia-Bonnefil, P. (2008). The Yin and Yang of YY1 in the nervous system. J Neurochem.

 

Shen, S., and Casaccia-Bonnefil, P. (2008). Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci 35, 13-22.

Shen, S., Liu, A., Li, J. Casaccia-Bonnefil, P. (2008) Epigenetic memory loss in the oligodendrocyte lineage cells in the aging brain. Neurobiology of Aging, 29(3):452-63.

2007

 

He, Y., Sandoval, J., and Casaccia-Bonnefil, P. (2007). Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1. Neuron Glia Biol 3, 221-231.

He, Y., Dupree, J., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., and Casaccia-Bonnefil, P. (2007).The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron 55, 217-230.

Werner, H. B., Kuhlmann, K., Shen, S., Uecker, M., Schardt, A., Dimova, K., Orfaniotou, F., Dhaunchak, A., Brinkmann, B. G., Mobius, W., et al. (2007). Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci27, 7717-7730.

Liu, A., Han, Y. R., Li, J., Sun, D., Ouyang, M., Plummer, M. R., and Casaccia-Bonnefil, P. (2007). The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. J Neurosci27, 7339-7343. Reviewed in Nature Neuroscience Review 8, 573

2006

Mastronardi, F. G., Wood, D. D., Mei, J., Raijmakers, R., Tseveleki, V., Dosch, H. M., Probert, L., Casaccia-Bonnefil, P., and Moscarello, M. A. (2006). Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation. J. Neurosci. 26, 11387-11396.

 

Liu, A. , Li, J. ,Marin-Husstege, M., Kageyama R., Fan, Y, Gelinas, C, Casaccia-Bonnefil, P. (2006). A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players EMBO J, 25(20):4833-42.

Marin-Husstege, M., He Y., Li, J., Kondo, T., Sablitzky, F. Casaccia-Bonnefil, P. (2006). Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings. Glia, 54:285-296.

Gil-Perotin S, Marin-Husstege M, Li J, Soriano-Navarro M, Zindy F, Roussel MF, Garcia-Verdugo JM, Casaccia-Bonnefil P. (2006). Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors. J Neurosci.;26:1107-16.

 

Cunliffe, V., Casaccia-Bonnefil, P. (2006) Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS. Mech. Devel., 123:24-30.

2005

Gokhan, S., Marin-Husstege, M., Yu Yung , S, Fontanez, D., Casaccia-Bonnefil, P.*, Mehler, MF (2005). Coordinate Regulation of Homeodomain and Basic Helix-Loop-Helix Transcription Factors Differentially Regulate Myelin Basic Protein Gene Expression. J. Neurosci., 25:8311-21.

Shen, S., Li, J., Casaccia-Bonnefil, P.* (2005). Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. J. Cell Biol. 169: 577-589.

Bansal, R., Marin-Husstege,M., Winkler,S., Casaccia-Bonnefil P. (2005). FGF2-induced entry into S-phase is accompanied by increased levels of the cell cycle inhibitor p21Waf/Cip1: a paradoxical role for this molecule in the oligodendrocyte lineage. J. Neurosci. Res., 80:360-8

 

Liu , A, Stadelman C., Mastronardi F., Moscarello M., Sobel A., Casaccia-Bonnefil, P., (2005). Inhibitors of morphological differentiation of oligodendrocyte progenitors are inappropriately re-expressed in the brain of patients with multiple sclerosis. J Neurosci. Jan 19;25(3):737-47

 

Marin-Husstege, M., Muggironi, M., Raban, D., Skoff. R, Casaccia-Bonnefil P. (2004). Oligo- dendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones. Dev. Neurosci., 26:245-54.

Crockett, D. Burnashey, M.,Muggironi, M.,Garcia, C., Casaccia-Bonnefil, P. (2005). The number of oligodendrocyte progenitors recruited to the lesioned spinal cord is modulated by the levels of the cell cycle regulatory protein p27Kip1. Glia, 49(2):301-8.

2004

 

Kim, D., Zhao, X., Tu, C., Casaccia-Bonnefil, P., Chao, MV (2004). The neurotrophins prevent apoptotic but not necrotic cell death following neuronal injury by signaling through their TRK receptor. J. Neurosurgery

2003

Liu A., M., Muggironi, M., Casaccia-Bonnefil, P. (2003). Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. Glia,44(3):264-74.

  Petrone A., Dusa, A., Bianchi R., Casaccia-Bonnefil, P., Arancio, O., Sap.J. (2003). Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J., 22:4121-4131.

2002

Marin-Husstege, M., Muggironi, M., Liu A.X., Casaccia-Bonnefil, P. (2002). Inhibition of histone deacetylase activity is necessary for oligodendrocyte lineage progression. J. Neurosci. 22(23): 10333-45.

Osterhout, D.J., Marin-Husstege, M., Abano, P., Casaccia-Bonnefil, P. (2002) Molecular mechanisms of enhanced susceptibility to apoptosis in differentiating oligodendrocytes. J. Neurosci. Res. 69(1): 24-29.

Doetsch, F. Verdugo, J.G., Caille I, Chao MV, Alvarez-Buyilla, Casaccia-Bonnefil, P., (2002) Lack of the cell cycle inhibitor p27Kip1 results in selective increase of transit amplifying cells for adult neurogenesis. J. Neurosci, 22:2256-2264.

Miskimins, R., Srinivasan, R., Marin-Hincapie M., Miskimins K., Casaccia-Bonnefil, P. (2002). P27Kip1 enhances myelin basic protein gene promoter activity. J. Neurosci. Res., 67:100-105.
1999-2001

2001

Zeuzula, J., Casaccia-Bonnefil,P., Osterhout, D.J., Levine, J., Chao, M.V. Koff, A. (2001). P21Cip1 is required for the differentiationn of oligodendrocytes independently of cell cycle withdrawal. EMBO reports 2: 27-34.

2000

 

Gentry J., Casaccia-Bonnefil, P., Carter, B.D. (2000). Nerve Growth Factor activation of Nuclear Factor Kb through its p75 is an anti-apoptotic signal in RN22 Schwannoma cells. J. Biol. Chem. 275: 7558-7565.

1999

Dowling, P., Raval, S., Husar,W., Casaccia-Bonnefil, P., Chao, M.V., Cook, S., Blumberg, B. (1999). Expression of the p75 neurotrophin receptor on oligodendrocytes in multiple sclerosis plaques. Neurology, 53(8):1676-82.

 

Casaccia-Bonnefil, P., Hardy, R.J., Teng, K.K., Levine, J.M., Koff, A., Chao, M.V. (1999). Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development, 126(18):4027-37.

Gu, C.G., Casaccia-Bonnefil, P., Srinivasan A., Chao, M.V. (1999). Oligodendrocyte apoptosis mediated by caspase activation. J. Neuroscience, 19(8):3043-3049.

   
Casaccia Laboratory
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One Gustave L. Levy Place
Box 1065
New York, NY 10029

Courier Address:
Mount Sinai School of Medicine
1425 Madison Avenue, Room 9-23
New York, NY 10029