The clem laboratory
of emotional brain plasticity



  Clem RL, Schiller D. New Learning and Unlearning: Strangers or Accomplices in Threat Memory Attenuation? Trends Neurosci. 2016 May;39(5):340-51. doi: 10.1016/j.tins.2016.03.003. Epub 2016 Apr 12.
  Elizabeth K. Lucas, Anita M. Jegarl, Hirofumi Morishita, Roger L. Clem. Multimodal and Site-Specific Plasticity of Amygdala Parvalbumin Interneurons after Fear Learning. Neuron. 2016 Jul 12. pii: S0896-6273(16)30310-5. doi: 10.1016/j.neuron.2016.06.032. [Epub ahead of print]


  Arruda-Carvalho M, Clem RL. Prefrontal-amygdala fear networks come into focus. Front Syst Neurosci. 2015 Oct 30;9:145. doi: 10.3389/fnsys.2015.00145. eCollection 2015



Arruda-Carvalho M, Clem RL. Pathway-Selective Adjustment of Prefrontal-Amygdala Transmission during Fear Encoding.J Neurosci. 2014 Nov 19;34(47):15601-9. doi: 10.1523/JNEUROSCI.2664-14.2014.


Steinfurth EC, Kanen JW, Raio CM, Clem RL, Huganir RL, Phelps EA. Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans. Learn Mem. 2014 Jun 16;21(7):338-41.


Lucas, EK, A Jegarl and RL Clem. 2014. Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes. Behavioural Brain Research: advance online Aug 12.



Clem, RL, RL Huganir. 2013. Norepinephrine enhances a discrete form of long-term depression during fear memory storage. J Neurosci 33(29): 11825-32. PMC3713724.


Ming-Sia, G, RL Clem and RL Huganir. 2013. The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Science 342(6161):987-91.


  Anggono V, Clem RL, Huganir RL. PICK1 loss of function occludes homeostatic synaptic scaling. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb; 31(6).



Gerkin RC, Clem RL, Shruti S, Kass RE, Barth AL. Cortical up state activity is enhanced after seizures: a quantitative analysis. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2010 Dec; 27(6).


Clem RL, Huganir RL. Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science (New York, N.Y.) 2010 Nov; 330(6007).


Clem RL, Anggono V, Huganir RL. PICK1 regulates incorporation of calcium-permeable AMPA receptors during cortical synaptic strengthening. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 May; 30(18).



Tran TS, Rubio ME, Clem RL, Johnson D, Case L, Tessier-Lavigne M, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature 2009 Dec; 462(7276).



Shruti S, Clem RL, Barth AL. A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons. Neurobiology of disease 2008 Jun; 30(3).


Clem RL, Celikel T, Barth AL. Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex. Science (New York, N.Y.) 2008 Jan; 319(5859).



Clem RL, Barth A. Pathway-specific trafficking of native AMPARs by in vivo experience. Neuron 2006 Mar; 49(5).



Clump DA, Clem R, Qian Y, Guappone-Koay A, Berrebi AS, Flynn DC. Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain. Journal of neurobiology 2003 Feb; 54(3).

Clem Laboratory
Lab location: CSM 9-301
Office location: CSM 9-112
Office: (212) 824-8976
Lab Address:
Mount Sinai School of Medicine
Hess Center for Science and Medicine
1470 Madison Ave
New York, NY 10029

Admin Phone: (212) 659 - 5993
Admin Fax: (212) 849 - 2611
Mount Sinai School of Medicine
One Gustave L. Levy Place
Box 1065
New York, NY 10029

Courier Address:
Mount Sinai School of Medicine
New York, NY 10029