neuro
ellis-davies lab
OPTICAL METHODS & NEUROPHYSIOLOGY

In the past 30 years the use of fluorescence imaging in biological sciences has been as important as DNA-based methods advancing our understanding in almost every field. (Nobel Prizes for GFP (2008) and super resolution imaging (2014) are testament to this.) My work during this period has pioneered the use of light to control cell function, the optical tools we have made have proved to be conceptual fundamental enabling technologies. Specifically I have developed caged calcium probes, which have enabled 100s of experiments in many areas of biology and chemistry. The second focus of my research is the development of caged neurotransmitters. We have published several seminal papers in this field. These probes have also enabled many important discoveries by many neuroscientists all over the world. The goal of my current and future work is to be equally transformative. Thus my research at Mount Sinai has involved developing new probes that allow chromatically selective, multi-color stimulation of cellular processes. With our recent work we have taken optical stimulation of cells out of the "monochrome era" so as to enable bi-directional control of neuronal signaling with different colors of light for the first time.

PUBLICATIONS


Graham Ellis-Davies, PhD

My lab uses organic chemistry to develop new optical methods for cell physiology.

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