Haghighi Laboratory


Job opportunities are available in the Laboratory of Medical Epigenetics. Internationally regarded for its dedication to medical science, Mount Sinai is home to an array of leading research institutes, centers, and laboratories, all of which work toward rapidly translating advances in basic science into innovative patient care. Mount Sinai's Fishberg Department of Neuroscience, a major component of Mount Sinai's Friedman Brain Institute, sponsors innovative research in basic and translational neuroscience at the molecular, cellular, systems, and behavioral levels. The Haghighi laboratory is studying the epigenetic profiles of human brain development and its emerging role in gene regulation, as well as its fundamental importance for our understanding of normal and pathological neuronal function. Epigenetic patterns in the genome vary among tissues and cell types in normal and pathological states.

A major unanswered question is how epigenetics plays a role in neuronal development and how alterations in normal epigenetic processes during development lead to neurodevelopmental diseases such as autism and schizophrenia. Next-gen sequencing technologies now allow a global view of whole genome epigenetic profiles. Studies involve statistical and bioinformatic analyses of data from whole genome DNA and histone methylation profiling via BS-seq and ChIP-seq to detect differentially methylated regions associated with disease and their potential function through genomic data mining. This interdisciplinary group offers an excellent environment to uncover new fundamental principles and regulatory mechanisms in this emerging area of neural-epigenetics.