Haghighi Laboratory

Selected Publications


Haghighi F, Ge Y, Chen S, Xin Y, Umali MU, De Gasperi R, Gama Sosa MA, Ahlers ST, Elder GA. Neuronal DNA Methylation Profiling of Blast-related Traumatic Brain Injury (TBI). J Neurotrauma. 2015 Jan 16. [Epub ahead of print] PubMed PMID:25594545.


Milekic M, Xin Y, O'Donnell A, Kumar K, Bradley-Moore M, Malaspina D, Paul S, Moore H, Ge Y, Edwards J, Haghighi F, and Gingrich J. (2014). Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression. Molecular Psychiatry [Epub ahead of print]. PMID: 25092244

Haghighi F, Xin Y, Chanrion B, O'Donnell AH, Ge Y, Dwork AJ, Arango V, and Mann JJ. (2014). Increased DNA Methylation in the Suicide Brain. Dialogues Clin Neurosci, 16(3):430-8. PMID: 25364291


Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejnowski TJ, Behrens MM, and Ecker JR. (2013). Global epigenomic reconfiguration during mammalian brain development. Science, 341(6146), 1237905. PMID: 23828890

Deo AJ, Huang YY, Hodgkinson CA, Xin Y, Oquendo MA, Dwork AJ, Arango V, Brent DA, Goldman D, Mann JJ, and Haghighi F. (2013). A large-scale candidate gene analysis of mood disorders: evidence of neurotrophic tyrosine kinase receptor and opioid receptor signaling dysfunction. Psychiatr Genet, 23(2), 47-55. PMID: 23277131


Xin Y, Chanrion B, O'Donnell AH, Milekic M, Costa R, Ge Y, and Haghighi FG. (2012). MethylomeDB: a database of DNA methylation profiles of the brain. Nucleic Acids Res, 40(Database issue): D1245-9. PMID: 22140101


Xin Y, O'Donnell AH, Ge Y, Chanrion B, Milekic M, Rosoklija G, Stankov A, Arango V, Dwork AJ, Mann JJ, Gingrich J, Haghighi F. (2011). Role of CpG Context and Content in Evolutionary Signatures of Brain DNA Methylation. Epigenetics, 6(11), 1308-18. PMID: 22048252

Xin Y, Ge Y, Haghighi FG. (2011). Methyl-Analyzer—whole genome DNA methylation profiling. Journal of Bioinformatics, 27(16), 2296-7. PMID:21685051

Xin Y, Chanrion B, Liu M, Galfalvy H, Costa R, Ilievski B, Rosoklija G, Arango V, Dwork A, Mann JJ, TyckoB, Haghighi F. Genome-Wide Divergence of DNA Methylation Marks in Cerebral and Cerebellar Cortices. PLoS One. 5(6), e11357. PMID: 20596539


Kinnally EL, Capitanio JP, Leibel R, Deng L, LeDuc C, Haghighi, F and Mann, JJ. (2010). Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes, Brain and Behavior, 9, 575-582.

Edwards JR, O'Donnell AH, Rollins RA, Peckham H, Lee C, Milekic MH, Chanrion B, Fu Y, Su T, Hibshoosh H, Gingrich JA, Haghighi F, Nutter R, Bestor TH. (2010). Chromatin and Sequence Features that Define the Fine and Gross Structure of Genomic Methylation Patterns. Genome Res 20(7), 972-80. PMID: 20488932

Deo AJ, Costa R, DeLisi LE, DeSalle R, Haghighi F. (2010). A Novel Analytical Framework for Dissecting the Genetic Architecture of Behavioral Symptoms in Neuropsychiatric Disorders. PLoS ONE. 5(3), e9714. doi:10.1371/journal.pone.0009714. PMID: 20300526


Haghighi F, Bach-Mizrachi H, Huang YY, Arango V, Shi S, Dwork AJ, Sheng HT, Morozova I, Ju J, Russo JJ , Mann JJ. (2008). Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression. Molecular Psychiatry, 13, 813–820. PMID: 18180764

Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, Li K, Murty VV, Schupf N, and Vilain E, Mitzi M, Haghighi F, Tycko B. (2008). Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nature Genetics, 40(7), 904. PMID: 18568024

Das R, Dimitrova N, Xuan ZY, Rollins RA, Haghighi F, Edwards JR, Ju J, Bestor TH and Zhang MQ.


Rollins RA*, Haghighi F*, Edwards JR, Das R, Zhang MQ, Ju J, and Bestor TH. (2006) Large-scale structure of genomic methylation patterns. Genome Res., 16(2),157-63.*Authors contributed equally. PMID: 16365381