neuro
hof lab
laboratory of neuromorphology

PUBLICATIONS

2016

  Ding S.L., Royall J.J., Sunkin S.M., Ng L., Facer B.A.C., Lesnar P., Guillozet-Bongaarts A., McMurray B., Szafer A., Dolbeare T.A., Stevens A., Tirrell L., Benner T., Caldejon S., Dalley R.A., Dee N., Lau C., Nyhus J., Reding M., Riley Z.L., Sandman D., Shen E., van der Kouwe A., Varjabedian A., Write M., Zollei L., Dang C., Knowles J.A., Koch C., Phillips J.W., Sestan N., Wohnoutka P., Zielke H.R., Hohmann J.G., Jones A.R., Bernard A., Hawrylycz M.J., Hof P.R., Fischl B., Lein E.S. (2016) Comprehensive cellular-resolution atlas of the adult human brain. J. Comp. Neurol. 524(16):3127-3481, doi:10.1002/cne.24080.
  Babic Leko M., Borovecki F., Dejanovic N., Hof P.R., Simic G. (2016) Predictive value of cerebrospinal fluid visinin-like protein-1 levels for Azheimer's disease early detection and differential diagnosis in patients with mild cognitive impairment. J. Alzheimer Dis. 50, 765-778.
  Perez S.E., Sherwood C.C., Cranfield M.R., Erwin J.M., Mudakikwa A., Hof P.R., Mufson E.J. (2016) Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol. Aging 39, 195-201.
  Stimpson C.D., Barger N., Taglialatella J.P., Gendron-Fitzpatrick A., Hof P.R., Hopkins W.D., Sherwood C.C. (2016) Differential serotonergic innervation of the amygdala of bonobos and chimpanzees. Soc. Cogn. Affect. Neurosci. 11, 413-422.
  Jacobs B., Lee L., Schall M., Raghanti M.A., Lewandowski A.H., Kottwitz J.J., Roberts J.F., Hof P.R., Sherwood C.C. (2016) Neocortical neuronal morphology in the newborn giraffe (Giraffa camelopardalis tippelskirchi) and African elephant (Loxodonta africana). J. Comp. Neurol. 524, 257-287.
  Raghanti M.A., Edler M.K., Stephenson A.R., Wilson L.J., Hopkins W.D., Ely J.J., Erwin J.M., Jacobs B., Hof P.R., Sherwood C.C. (2016) Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: a comparative analysis of the primate basal ganglia. J. Comp. Neurol. 524, 2217-2129.
  Lipovich L., Hou Z.C., Jia H., Sinkler C., McGowen M., Sterner K.N., Weckle A., Sugalski A.B., Pipes L., Gatti D.L., Mason C.E., Sherwood C.C., Hof P.R., Kuzawa C.W., Grossman L.I., Goodman M., Wildman D.E. (2016) High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans. J. Comp. Neurol. 524, 288-308.
  Xuan B., Mackie M.A., Spagna A., Wu T., Tian Y., Hof P.R., Fan J. (2016) The activation of interactive attentional networks. NeuroImage 129, 308-319.

2015

  Wegiel J., Flory M., Kuchna I., Nowicki K., Ma S., Imaki H., Wegiel J., Frackowiak J., Kolecka B., Wierzba-Bobrowicz T., London E., Wisniewski T., Hof P.R., Brown T. (2015) Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults. Acta Neuropathol. Commun. 3, 2.
  Bozek K., Wei Y., Yan Z., Liu X., Xiong J., Sugimoto M., Tomita M., Pääbo S., Sherwood C.C., Hof P.R., Ely J.J., Li Y., Steinhauser D., Willmitzer L., Giavalisco P., Khaitovich P. (2015) Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues. Neuron 85, 695-702.
  Barks S.K., Calhoun M.E., Hopkins W.D., Cranfield M.R., Paterson P.E., Mudakikwa A., Erwin J.M., Stoinski T.S., Hecht E.E., Hof P.R., Sherwood C.C. (2015) Brain organization of gorillas reflects species differences in ecological specialization. Am. J. Phys. Anthropol. 156, 252-262.
  Coskren P.J., Luebke J.I., Kabaso D., Wearne S.L., Yadav A., Rumbell T., Hof P.R., Weaver C.M. (2015) Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. J. Comput. Neurosci. 38, 263-283.
  Luebke J.I., Medalla M., Amatrudo J.M., Weaver C.M., Crimins J.L., Hunt B., Hof P.R., Peters A. (2015) Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cereb. Cortex 25, 1454-1468.
  Uppal N., Puri R., Yuk F., Janssen W.G.M., Bozdagi-Günal O., Harony-Nicolas H., Dickstein D.L., Buxbaum J.D., Hof P.R. (2015) Ultrastructural changes in the CA1 of Shank3-deficient mice. Mol. Autism 6, 41.
  Gu X., Eilam-Stock T., Zhou T., Anagnostou E., Kolevzon A., Soorya L., Hof P.R., Friston K.L., Fan J. (2015) Autonomic and brain responses associated with empathy deficits in autism spectrum disorder. Hum. Brain Mapp. 36, 3323-3338.
  Raghanti M.A., Spurlock L.B., Treichler F.R., Weigel S.E., Stimmelmayr R., Butti C., Thewissen J.G.M.H., Hof P.R. (2015) An analysis of von Economo neurons in the cerebral cortex of cetaceans, artiodactyls, and perissodactyls. Brain Struct. Funct. 220, 2303-2314.
  Bauernfeind A.L., Reyzer M.L., Caprioli R.M., Ely J.J., Babbitt C.C., Wray G.A., Hof P.R., Sherwood C.C. (2015) High spatial resolution proteomic comparison of the brain in humans and chimpanzees. J. Comp. Neurol. 523, 2043-2061.
  Brautigam H., Moreno C.L., Steele J.W., Bogush A., Dickstein D.L., Kwok J.B.J., Schofield P.R., Thinakaran G., Mathews P.M., Hof P.R., Gandy S., Ehrlich M.E. (2015) Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Sci. Rep. 5, 17042.

2014

Barks S.K., Bauernfeind A.L., Bonar C.J., Cranfield M.R., de Sousa A.A., Erwin J.M., Hopkins W.D., Lewandowski A.H., Mudakikwa A., Phillips K.A., Raghanti M.A., Stimpson C.D., Hof P.R., Zilles K., Sherwood C.C. (2014) Variable temporoinsular cortex neuroanatomy in primates suggests bottleneck effect in eastern gorillas. J. Comp. Neurol. 522, 844-860.

Eilam-Stock T., Xu P., Cao M., Gu X., Van Dam N.T., Anagnostou E., Kolevzon A., Soorya L., Park Y., Siller M., He Y., Hof P.R., Fan J. (2014) Abnormal autonomic and associated brain activities during rest in autism spectrum disorder. Brain 137, 153-171.

Uppal N., Giannatiempo I., Wicinski B., Schmeidler J., Heinsen H., Schmitz C., Buxbaum J.D., Hof P.R. (2014) Neuropathology of the posteroinferior occipital gyrus in children with autism. Mol. Autism. 5, 17.

Guillozet-Bongaarts A.L., Hyde T.M., Dalley R.A., Hawrylycz M.J., Henry A., Hof P.R., Hohmann J., Jones A.R., Kuan C.L., Royall J., Shen E., Swanson B., Zeng H., Kleinmann J.E. (2014) Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol. Psychiatry 19, 478-485.

Butti C., Fordyce R.E., Raghanti M.A., Gu X., Bonar C.J., Wicinski B.A., Wong E.W., Roman J., Brake A., Eaves E., Spocter M.A., Tang C.Y., Jacobs B., Sherwood C.C., Hof P.R. (2014) The cerebral cortex of the pygmy hippopotamus, Hexaprotodon liberiensis (Cetartiodactyla, Hippopotamidae): MRI, cytoarchitecture, and neuronal morphology. Anat. Rec. 297, 670-700.

Bozek K., Wei Y., Yan Z., Liu X., Xiong J., Sugimoto M., Tomita M., Pääbo S., Pieszek R., Sherwood C.C., Hof P.R., Ely J.J., Steinhauser D., Willmitzer L., Bangsbo J., Hansson O., Call J., Giavalisco P., Khaitovich P. (2014) Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness. PLoS Biol. 12(5), e1001871.

Uppal N., Wicinski B., Buxbaum J.D., Heinsen H., Schmitz C., Hof P.R. (2014) Neuropathology of the anterior midcingulate cortex in young children with autism. J. Neuropathol. Exp. Neurol. 73, 891-902.

2013

Van Dam N.T., Sano M., Mitsis E.M., Grossman H.T., Gu X., Park Y., Hof P.R., Fan J. (2013) Functional neural correlates of attentional deficits in amnestic mild cognitive impairment. PLoS One 8(1), e54035.

DeFelipe J., López-Cruz P.L., Benavides-Piccione R., Bielza C., Larrañaga P., Anderson S., Burkhalter A., Cauli B., Fairén A., Feldmeyer D., Fishell G., Fitzpatrick D., Freund T.F., González-Burgos G., Hestrin S., Hill S., Hof P.R., Huang J., Jones E.G., Kawaguchi Y., Kisvarday Z., Kubota Y., Lewis D.A., Marín O., Markram H., McBain C.J., Meyer H.S., Monyer H., Nelson S.B., Rockland K., Rossier J., Rubinstein J.L.R., Rudy B., Scanziani M., Shepherd G.M., Sherwood C.C., Staiger J.F., Tamás G., Thomson A., Wang Y., Yuste R., Ascoli G.A. (2013) New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat. Rev. Neurosci. 14, 202-216.

Höistad M., Heinsen H., Wicinski B., Schmitz C., Hof P.R. (2013) Stereological assessment of the dorsal anterior cingulate cortex in schizophrenia: absence of changes in neuronal and glial densities. Neuropathol. Appl. Neurobiol. 39, 348-361.

Bianchi S., Stimpson C.D., Duka T., Larsen M.D., Janssen W.G.M., Collins Z., Bauernfeind A.L., Schapiro S.J., Baze W.B., McArthur M.J., Hopkins W.D., Wildman D.E., Lipovich L., Kuzawa C.W., Jacobs B., Hof P.R., Sherwood C.C. (2013) Synaptogenesis and development of pyramidal neuron dendritic morphology in the chimpanzee neocortex resembles humans. Proc. Natl. Acad. Sci. USA 110 (Suppl. 2), 10395-10401.

Gu X, Hof PR, Friston KL, Fan J. Anterior insular cortex and emotional awareness. J Comp Neurol 2013;521:3371-3388.PMID: 23749500
Gu X, Liu X, Van Dam NT, Hof PR, Fan J. Cognition-emotion integration in the anterior insular cortex. Cereb Cortex. 2013;23:20-27. PMID: 22275476

2012

Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. J Neurosci. 2012;32:13644-13660. PMID: 23035077

Yadav A, Gao YZ, Rodriguez A, Dickstein DL, Wearne SL, Luebke JI, Hof PR, Weaver CM. Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells. J Comp Neurol. 2012;520:2888-2902. PMID: 22315181

Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, Cartagena PM, Chakravarty MM, Chapin M, Chong J, Dalley RA, Daly BD, Dang C, Datta S, Dee N, Dolbeare TA, Faber V, Feng D, Fowler DR, Goldy J, Gregor BW, Haradon Z, Haynor DR, Hohmann JG, Horvath S, Howard RE, Jeromin A, Jochim JM, Kinnunen M, Lau C, Lazarz ET, Lee C, Lemon TA, Li L, Li Y, Morris JA, Overly CC, Parker PD, Parry SE, Reding M, Royall JJ, Schulkin J, Sequeira PA, Slaughterbeck CR, Smith SC, Sodt AJ, Sunkin SM, Swanson BE, Vawter MP, Williams D, Wohnoutka P, Zielke HR, Geschwind DH, Hof PR, Smith SM, Koch C, Grant SG, Jones AR. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489:391-399. PMID: 22996553
Zeng H, Shen EH, Hohmann JG, Oh SW, Bernard A, Royall JJ, Glattfelder KJ, Sunkin SM, Morris JA, Guillozet-Bongaarts AL, Smith KA, Ebbert AJ, Swanson B, Kuan L, Page DT, Overly CC, Lein ES, Hawrylycz MJ, Hof PR, Hyde TM, Kleinman JE, Jones AR. Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell. 2012;149:483-496. PMID: 22500809
  Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AM, Sestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR, Sherwood CC. Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci USA. 2012;109:16480-16485. PMID: 23012402

Spocter MA, Hopkins WD, Barks SK, Bianchi S, Hehmeyer AE, Anderson SM, Stimpson CD, Fobbs AJ, Hof PR, Sherwood CC. Neuropil distribution in the cerebral cortex differs between humans and chimpanzees. J Comp Neurol. 2012;520:2917-2929. PMID: 22350926

Barger N, Stefanacci L, Schumann CM, Sherwood CC, Annese J, Allman JM, Buckwalter JA, Hof PR, Semendeferi K. Neuronal populations in the basolateral nuclei of the amygdala are differentially increased in humans compared with apes: a stereological study. J Comp Neurol. 2012;520:3035-3054. PMID: 22473387
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012;71:362-381. PMID: 22487856

Jacot-Descombes S, Uppal N, Wicinski B, Santos M, Schmeidler J, Giannakopoulos P, Heinsen H, Schmitz C, Hof PR. Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism. Acta Neuropathol. 2012;124:67-79. PMID: 22467063

Fan J, Xu P, Van Dam NT, Eilam-Stock T, Gu X, Luo Y, Hof PR. Spontaneous brain activity relates to autonomic arousal. J Neurosci. 2012;32:11176-11186. PMID: 22895703

Gu X, Gao Z, Wang X, Liu X, Knight RT, Hof PR, Fan J. Anterior insular cortex is necessary for empathetic pain perception. Brain. 2012;135:2726-2735. PMID: 22961548

Fan J, Bernardi S, Dam NT, Anagnostou E, Gu X, Martin L, Park Y, Liu X, Kolevzon A, Soorya L, Grodberg D, Hollander E, Hof PR. Functional deficits of the attentional networks in autism. Brain Behav. 2012;2:647-660. PMID: 2313991

2011

Fan J., Gu X., Liu X., Guise K.G., Park Y., Martin L., de Marchena A., Tang C.Y., Minzenberg M.J., Hof P.R. (2011) Involvement of the anterior cingulate and frontoinsular cortices in rapid processing of salient facial emotional information. NeuroImage 54, 2539-2546.

2010

  Bozdagi O., Sakurai T., Papapetrou D., Wang X., Dickstein D.L., Scattoni M.L., Takahashi N., Kajiwara Y. Harris M.J., Saxena R., Katz A.M., Silverman J.L., Yang M., Krug L., Zhou Q., Crawley J.N., Hof P.R., Buxbaum J.D. (2010) Shank3 haploinsufficiency leads to altered synaptic development, transmission, and plasticity as well as to social deficits. Mol. Autism 1, 15, doi:10.1186/2040-2392-1-15.
Segal D., Haznedar M.M., Hazlett E., Entis J.J., Newmark R.E., Torosjan Y., Schneiderman J.S., Friedman J.I., Chu K.W., Tang C.Y., Buchsbaum M.S., Hof P.R. (2010) Diffusion tensor anisotropy in the cingulate gyrus in schizophrenia. NeuroImage 50, 357-365.
Gu X., Liu X., Guise K.G., Naidich T.P., Hof P.R., Fan J. (2010) Functional dissociation of the frontoinsular and anterior cingulate cortices in empathy for pain. J. Neurosci. 30, 3739-3744.
  Luebke JI, Weaver C, Rocher AB, Rodriguez A, Crimins JL, Dickstein DL, Wearne SL, Hof PR. Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models. Brain Struct. Funct. 2010; 214: 181-199.

2009

Kabaso D, Coskren PJ, Henry BI, Hof PR, Wearne S.L. The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in aging. Cereb. Cortex 2009; 19: 2248-2268.
Butti C, Sherwood CC, Hakeem AY, Allman JM, Hof PR. Total number and volume of von Economo neurons in the cerebral cortex of cetaceans. J. Comp. Neurol. 2009; 515: 243-259.

2008

Akram A, Christoffel D, Rocher AB, Bouras C, Kovari E, Perl DP, Morrison JH, Herrmann FR, Haroutunian V, Giannakopoulos P, Hof PR. Stereologic estimates of total spinophilin-immunoreactive spine numbers in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease. . Neurobiol. Aging 2008; 29: 1296-1307.
  Rodriguez A, Ehlenberger DB, Dickstein DL, Hof PR, Wearne SL. Automated three-dimensional detection and classification of dendritic spines from fluorescence microscopy. Public Lib. Sci. One 2008; 3(4 )-e1997.

Radley JJ, Rocher AB, Rodriguez A, Ehlenberger DB, Dammann M, McEwen BS, Morrison JH, Wearne SL, Hof PR. Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex. J. Comp. Neurol 2008; 507: 1141-1150.

2007

Hof PR, Van der Gucht E. The structure of the cerebral cortex of the humpback whale, Megaptera novaeangliae (Cetacea, Mysticeti, Balaenopteridae). Anat. Rec 2007; 290: 1-31.

2006

Rodriguez A, Ehlenberger DB, Hof PR, Wearne SL. Rayburst sampling, an algorithm for automated three-dimensional shape analysis from laser scanning microscopy images.. Nature Protocols 2006; 1: 2152-2161.

2004

Hof PR, Morrison JH. The aging brain: morphomolecular senescence of cortical circuits. Trends Neurosci 2004; 27: 607-613.

2003

Bussiere T, Giannakopoulos P, Bouras C, Perl DP, Morrison JH, Hof PR. Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: a stereologic analysis of prefrontal cortex area 9. J. Comp. Neurol 2003; 463: 281-302.

   
Hof Laboratory
Lab Location: Hess 10 - 302
Office Location: Hess 10 - 118
Office: (212) 824 - 9302
Lab: (212) 824 - 9172
Lab Address:
Mount Sinai School of Medicine
Hess Center for Science & Medicine
1470 Madison Avenue
New York, NY 10029
Admin Phone: (212) 824 - 9326
Admin Fax: (646) 537 - 9585
Mount Sinai School of Medicine
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Box 1639
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