laboratory of synaptic circuit development and plasticity



  Friedman LG, Benson Dl, Huntley GW. Cadherin-based trans-synaptic networks in establishing and modifying neural connectivity. Curr Top Dev Biol 2015 112:415-465.
  Friedman LG, Riemslagh FW, Sullivan JM, Mesias R, Williams FM, Huntley GW, Benson DL. (2015) Cadherin-8 expression, synaptic localization and molecular control of neuronal form in prefrontal cortico-striatal circuits. J Comp Neurol 523:75-92.


  Fargali, S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW , Phillips GR, Benson DL, Bartolomucci A, Salton SR. 2014 The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J 2014 28:2120-2133.

Carcea I, Patil SB, Robison AJ, Mesias R, Huntsman MM, Froemke RC, Buxbaum JD, Huntley GW, Benson DL. (2014) Maturation of cortical circuits requires Sema 7A. Proc Natl Acad Sci USA 111:13978-13983.


Aujla P, Huntley GW. (2014) Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry. J Comp Neurol 522:1249-1263.

  Nikitczuk, JS, Patil SB, Scarpa J, Shapiro ML, Benson DL, Huntley GW. (2014) N-cadherin regulates molecular organization of excitatory and inhibitory synpatic circuits in adult hippocampus in vivo. Hippocampus 24:943-962.



Arguello A, Ye X, Bozdagi O, Pollonini G, Tronel S., Bambah-Mukku D, Huntley, GW, Platano D, Alberini C. (2013) CCAAT enhancer binding protein delta plays an essential role in memory consolidation and reconsolidation. J. Neurosci 33:3646-3658.


  Huntley, G.W. (2012) Synaptic circuit remodelling by matrix metalloproteinases in health and disease. Nat Rev Neurosci 2012 13:743-757.
  Benson DL, Huntley GW. Building and remodeling synapses. Hippocampus 2012 22:954-968.

Huntley GW, Elste AM, Patil SB, Bozdagi O, Benson DL, Steward, O. Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo. Hippocampus 2012 22:17-28.

  Mortillo, S., Elste, A., Ge, Y., Patil, S.B., Hsiao, K., Huntley, G.W. and Benson, D.L. (2012) Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic β 1-integrin. J. Comp. Neurol. 520:2041-2052.
  Benson, D.L. and Huntley, G.W. (2012) Synapse adhesion: a dynamic equilibrium conferring stability and flexibility. Curr Opin Neurobiol 22:397-404.


  Bozdagi, O., Wang, X., Martinelli, G.P., Prell, G., Friedrich, V.L., Huntley, G.W., and Holstein, G.R. (2011) Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazonline receptors. J. Neurophysiol. 105:1266-1275.

Suzuki, A., Stern, S.A., Bozdagi, O., Huntley, G.W. Walker, R.H., Magistretti, P., and Alberini, C.M. (2011) The astrocyte-neuron lactate-shuttle is required for long-term memory. Cell 144:810-823.


Patil, S., Brock, J.H., Colman, D.R., and Huntley, G.W. (2011) GDNF-dependent modulation of cadherins in spinal dorsal horn in relationship to neuropathic pain. Pain 152:924-935.


Parikh, P., Hao, Y., Hosseinkhani, M., Patil, S.B., Huntley, G.W., Tessier-Lavigne, M., and Zou, H. (2011) Regeneration of axons in injured spinal cord by activation of BMP/Smad1 signaling pathway in adult neurons. Proc Natl Acad Sci USA 108:E99-E107.


  Bozdagi O, Wang X-B, Nikitczuk JS, Anderson TR, Bloss EG, Radice GL, Zhou Q, Benson DL, Huntley GW. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J Neurosci 2010 30:9984-9989.
  Huntley, G.W., Elste, A.M., Patil, S.B., Bozdagi, O., Benson, D.L. and Steward, O. (2010) Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo. Hippocampus 22:17-28 (2012; ePub 2010 Sept. 16).
  Benson, D.L. and Huntley, G.W. (2010) Building and remodeling synapses. Hippocampus 22:954-968 (2012; ePub 2010 Sept 29).
  Bozdagi O, Wang X, Nikitczuk JS, Anderson TR, Bloss EG, Radice GL, Zhou Q, Benson DL, Huntley GW. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J Neurosci 2010; 39: 9984-9989.


  Wang, X-B., Bozdagi, O., Nikitczuk, J.S., Zhai, Z. W., Zhou, Q. and Huntley, G.W. (2008) Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately. Proc. Natl. Acad Sci USA 105:19519-19524.
  Bozdagi, O., Rich, E., Tronel, S., Shapiro, M.L., Alberini, C.M., Huntley, G.W. and Salton, S.R. (2008) The Neurotrophin-Inducible Gene Vgf Regulates Hippocampal Function and Behavior through a Brain-Derived Neurotrophic Factor-Dependent Mechanism. J. Neurosci. 28:9857-9869.
  Kichula, E.A. and Huntley, G.W. (2008) Developmental and comparative aspects of posterior medial thalamocortical innervation of barrel cortex in mice and rats. J. Comp. Neurol. 509:239-258.
  Bekirov, I.H., Nagy, V., Svoronos, A., Huntley, G.W. and Benson, D.L. (2008) Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway. Hippocampus 18:349-363.


  Nagy, V., Bozdagi, O., and Huntley, G.W. (2007) The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory. Learning and Memory 14:665-664.

Bozdagi, O., Nagy, V., Kwei, K.T., and Huntley, G.W. (2007) In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity. J. Neurophys. 98:334-344.


  Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R.M., Silva, A.J., Kaczmarek, L. and Huntley, G.W. (2006) Matrix metalloproteinase (MMP)-9 is required for hippocampal late-phase LTP and memory. J. Neurosci 26:1923-1934.


  Brock, J.H., Elste, A., and Huntley, G.W. (2004) Distribution and injury-induced plasticity of cadherins in relationship to identified synaptic circuitry in adult rat spinal cord. J. Neurosci. 2024 8806-8817.


  Poskanzer, K., Needleman, L.A., Bozdagi, O. and Huntley, G.W. (2003) N-cadherin regulates ingrowth and laminar targeting of thalamocortical axons. J. Neurosci. 23: 23:2294-2305.
  Lilliehook, C, Bozdagi, O, Yao, J, Gomez-Ramirez, M, Zaidi, NF, Wasco, W, Gandy, S, Santucci, AC, Haroutunian, V, Huntley GW, Buxbaum JD. (2003) Altered A-beta formation and long-term potentiation in a calsenilin knock-out. J Neurosci. 23:9097-9106.


  Huntley, G.W. (2002) Dynamic aspects of cadherin-mediated adhesion in synapse development and plasticity. Biol. Cell. 94:335-344.
  Huntley, G.W., Benson, D.L., and Colman, D.R. (2002) Structural remodeling of the synapse in response to physiological activity. Cell 108:1-4.
  Huntley, G.W. , Gil, O. and Bozdagi, O. (2002) The cadherin family of cell adhesion molecules: multiple roles in synaptic plasticity. The Neuroscientist 8:221-233.
  Huntley, G.W. and Jones, E.G. (2002) Introduction to a special issue on dynamical aspects of cortical structure and function. Neuroscience 111:707-708.
  Barlow, J.Z., Kelley, K.A., Bozdagi, O. and Huntley, G.W. (2002) Testing the role of the cell-surface molecule Thy-1 in regeneration and plasticity of connectivity in the CNS. Neuroscience 111:837-852.
  Jin, H.K., Carter, J.E., Huntley, G.W., Schuchman, E.H. (2002) Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span. J. Clin. Invest. 109:1183-1191.
  Shan, W., Yoshida, M., Wu, X.-R., Huntley, G.W. and Colman, D.R. (2002) Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure. J. Neurosci. Res. 69:292-304.
  Gil, O., Needleman, L. and Huntley, G.W. (2002) Developmental patterns of cadherin expresson and localization in relationship to compartmentalized thalamocortical terminations in rat barrel cortex. J. Comp. Neurol. 453:372-388.


  Benson, D.L, Colman, D.R. and Huntley, G.W. (2001) Molecules, maps and synapse specificity. Nature Reviews Neuroscience 2:899-909.


  Barlow, J.Z. and Huntley, G.W. (2000) Developmentally regulated expression of Thy-1 in structures of the mouse sensory-motor system. J. Comp. Neurol. 421:215-233.
  Bozdagi, O., Shan, W., Tanaka, H., Benson, D.L., and Huntley, G.W. (2000) Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation. Neuron 28:245-259.
  Benson, D.L., Schnapp, L.M., Shapiro, L. and Huntley, G.W. (2000) Making memories stick: cell adhesion molecules in synaptic plasticity.Trends in Cell Biol. 10:473-482.
  Tanaka, H., Shan, W., Phillips, G., Arndt, K., Huntley, G.W., Shapiro, L., Benson, D.L. and Colman, D.R. (2000) Molecular modification of N-cadherin in response to synaptic depolarization. Neuron 25:93-107.


  Huntley, G.W. and Benson, D.L. (1999) Neural (N)-Cadherin at Developing Thalamocortical Synapses Provides an Adhesion Mechanism for the Formation of Somatopically Organized Connections. J. Comp. Neurol. 407:453-471.


  Morrison, J.H., Hof, P.R. and Huntley, G.W. (1998) Neurochemical organization of primate visual cortex. In: Handbook of Chemical Neuroanatomy Vol 14: The Primate Nervous System, Part II, pp. 299-430.


  Huntley, G.W. (1997) Differential effects of abnormal tactile experience on shaping representation patterns in developing and adult motor cortex. J. Neurosci. 17:9220-9232.

Huntley, G.W. (1997) Correlation between patterns of horizontal connectivity and the extent of short-term representational plasticity in rat motor cortex. Cereb. Cortex 7:143-156. (commentary on this paper by Dr. John Donoghue appears in same issue, pps. 97-99)

  Shashidharan, P., Huntley, G.W., Murray, J.M., Buku, A., Moran, T., Walsh, M.J., Morrison, J.H., and Plaitakis, A. (1997) Immunohistochemical localization of neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody. Brain Res. 773:139-148.
  Gazzaley, A.H., Benson, D.L., Huntley, G.W. and Morrison, J.H. (1997) Differential subcellular regulation of NMDAR1 protein and mRNA in dendrites of dentate gyrus granule cells following perforant path transection. J. Neurosci. 17:2006-2017.
  Huntley, G.W., Vickers, J.C. and Morrison, J.H. (1997) Quantitative localization of NMDAR1 receptor subunit immunoreactivity in inferotemporal and prefrontal association cortices of monkey and human. Brain Res. 749:245-262.
  Huntley, G.W., Vickers, J.C. and Morrison, J.H. (1997) Cellular and synaptic localization of NMDA and non-NMDA receptor subunits in cerebral cortex: organizational features related to cortical circuitry, function and disease. Trends in Neurosci. 17:536-543.


  Morrison, J.H., Siegel, S.J., Gazzaley, A.H. and Huntley, G.W. (1996) Glutamate receptors: emerging links between subunit proteins and specific excitatory circuits in primate hippocampus and neocortex. The Neuroscientist 2:273-283.


  Vickers, J.C., Huntley, G.W., Hof, P.R., Bederson, J., DeFelipe, J. and Morrison, J.H. (1995) Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex. Brain Res. 671:175-180.
  Ripps, M.E., Huntley, G.W., Hof, P.R., Morrison, J.H. and Gordon, J.W. (1995) Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 92:689-693.

Vickers, J.C., Huntley, G.W. and Morrison, J.H. (1995) Excitatory amino acids and neurotoxicity in the human neocortex. In: Neurotransmitters in the Human Brain (Tracey, D., Stone, J. and Paxinos, G., eds.), Plenum Press, New York.


  Shashidharan, P., Huntley, G.W., Meyer,T., Morrison, J.H. and Plaitakis, A. (1994) Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain. Brain Res. 662:245-250.
  Huntley, G.W., Vickers, J.C., Janssen, W., Brose, N., Heinemann, S.F. and Morrison, J.H. (1994) Distribution and synaptic localization of immunocytochemically identified NMDA receptor subunit proteins in the sensory-motor cortex and visual cortices of monkey and human. J. Neurosci. 14:3603-3619.
  Brose, N., Huntley, G.W., Stern-Bach, Y., Morrison, J.H. and Heinemann, S.F. (1994) Differential Assembly of Coexpressed Glutamate Receptor Subunits in Neurons of Rat Cerebral Cortex J. Biol. Chem. 269:16780-16784.
  DeFelipe, J., Huntley, G.W., del Rio, M.R., Sola, R.G. and Morrison, J.H. (1994) Microzonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR2/3 and GluR5/6/7 in the human epileptogenic neocortex. Brain Res. 657:150-158.
  Jones, E.G., Huntley, G.W. and Benson, D.L. (1994) Alpha calcium/calmodulin dependent protein kinase II selectively expressed in a subpopulation of excitatory neurons in monkey sensory-motor cortex: comparison with GAD-67 expression. J.Neurosci. 14:611-629.


  Huntley, G.W., Rogers, S.W., Moran, T., Janssen, W., Archin, N., Vickers, J.C., Cauley, K., Heinemann, S.F. and Morrison, J.H. (1993) Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody which recognizes glutamate receptor subunits GluR5/6/7. J. Neurosci. 13:2965-2981.
  Evans, H.F., Huntley, G.W., Morrison, J.H. and Shine, J. (1993) Localisation of mRNA Encoding the Protein Precursor of Galanin in the Monkey Hypothalamus and Basal Forebrain. J. Comp. Neurol. 328:203-212.
  Rappaport, M.S., Sealfon, S.C., Prikhozhan, A., Huntley, G.W. and Morrison, J.H. (1993) Heterogeneous distribution of D1, D2 and D5 receptor mRNAs in monkey striatum. Brain Res. 616:242-250.
  Good, P.F., Huntley, G.W., Rogers, S.W., Heinemann, S.F. and Morrison, J.H. (1993) Organization and quantitative analysis of kainate receptor subunit GluR5/6/7 immunoreactivity in monkey hippocampus. Brain Res. 624:347-353.
  Vickers, J.C., Huntley, G.W., Edwards, A.M., Moran, T., Rogers, S.W., Heinemann, S.F. and Morrison, J.H. (1993) Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey. J Neurosci 13:2982-2992.


  Huntley, G.W., Benson, D.L., Isackson, P.J. and Jones, E.G. (1992) Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex. Dev. Brain Res. 70:53-63.
  Evans, H.F., Huntley, G.W., Morrison, J.H., Shine, J. and Paxinos, G. (1992) Localization of preprogalanin mRNA in the monkey hippocampal formation. Neurosci. Letts. 146:171-175.
  Rausell, E., Bae, C.S., Vinuela, A., Huntley, G.W. and Jones, E.G. (1992) Calbindin and parvalbumin cells in monkey VPL thalamic nucleus: distribution, laminar cortical projections and relations to spinothalamic terminations. J.Neurosci. 12:4088-4111.
  Huntley, G.W., Morrison, J.H., Prikhozhan, A. and Sealfon, S.C. (1992) Localization of multiple dopamine receptor subtype mRNAs in human and monkey cortex and striatum. Mol. Brain Res. 15:181-188.


  Huntley, G.W. and Jones, E.G. (1991) The emergence of architectonic field structure and areal borders in developing monkey sensory-motor cortex. Neuroscience 44:287-310.
  Huntley, G.W. and Jones, E.G. (1991) Relationship of intrinsic connections to forelimb movement representations in monkey motor cortex: A correlative anatomical and physiological study. J. Neurophysiol. 66:390-413.


  Huntley, G.W. and Jones, E.G. (1990) Cajal-Retzius neurons in developing monkey neocortex show immunoreactivity for calcium binding proteins. J. Neurocytol. 19:200-212.
  Huntley, G.W., de Blas, A.L. and Jones, E.G. (1990) GABAA receptor immunoreactivity in developing and adult monkey sensory-motor cortex. Exp. Brain Res. 82:510-535.


  Liu, X.-B., Jones, E.G., Huntley, G.W. and Molinari, M. (1989) Tachykinin immunoreactivity in terminals of the trigeminal lemniscus in adult and fetal monkey thalamus. Exp. Brain Res. 78:479-488.


  Huntley, G.W., Hendry, S.H.C., Killackey, H.P., Chalupa, L.M. and Jones, E.G. (1988) Temporal sequence of neurotransmitter expression by developing neurons of fetal monkey visual cortex. Dev. Brain Res. 43:69-96.


  Morrison, J.H., Lewis, D.A., Campbell, M.J. Huntley, G.W., Benson, D.L. and Bouras, C. (1987) A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease. Brain Research 416:331-336.
Huntley Laboratory
Hess CSM Building Floor 9th Floor Room 108
1470 Madison Avenue
New York, NY 10029

Tel: 212-824-8981
Fax: 646-537-9583

Lab Address:
Hess CSM Building Floor 9th Floor Room 302
1470 Madison Avenue
New York, NY 10029

Admin Phone: (212) 824 - 8967 
Admin Fax: (646) 537 - 9583
Mount Sinai School of Medicine
One Gustave L. Levy Place
Box 1065
New York, NY 10029

Courier Address:
Mount Sinai School of Medicine
New York, NY 10029