neuro
Hurd Laboratory
Molecular Neuropsychopharmacology

Selected Publications

2014

M Michaelides and YL Hurd. DREAMM: A biobehavioral imaging methodology for dynamic in vivo whole-brain mapping of cell type-specific functional networks. Neuropsychopharmacology, in press, 2014.

J Xu, Z Lu, M Xu, L Pan, Y Deng, X Xie, H Liu, S Ding, YL Hurd, G Pasternak, R Klein, L Cartegni, W-H Zhou, and Y-X Pan. A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1, via hnRNPH interactions. J. Neuroscience, Epub, Aug 13, 34:11048-11066, 2014. PMCID: PMC4131016. PMID: 25122903

A Alpar, G Tortoriello, D Calvigioni, M Niphakis, I Milenkovic, J Bakker, G Cameron, J Hanics, CV Morris, J Fuzik, Gabor Kovacs, B Cravatt, J Parnavelas, WD Andrews, YL Hurd, E Keimpema, and T Harkany. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signaling. Nature Communications, Epub, July 17, 2014. PMCID: PMC4110686. PMID: 25030704

Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. G9a influences neuronal subtype specification in striatum. Nat Neurosci. Epub, Mar 2. 2014. PMCID: PMC3972624. PMID: 24584053

Szutorisz H., J DiNieri, E Sweet, G Egervari, M Michaelides, J Carter, Y Ren, M Miller, R Blitzer, and YL Hurd. Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.;Neuropsychopharmacology, Epub, Jan 2, 2014. PMCID: PMC3988557. PMID: 24385132

Tortoriello G, CV Morris, A Alpar, J Fuzik, SL Shirran, D Calvigioni, E Keimpema, CH Botting, K Reinecke, T Herdegen, M Courtney, YL Hurd and T Harkany. Miswiring the brain: 9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO Journal, Epub Jan 27, 2014. PMCID: PMC4000086. PMID: 24469251

Trampush JW, MM Jacobs, YL Hurd, JH Newcorn, JM Halperin. Moderator Effects of Working Memory on the Stability of ADHD Symptoms by Dopamine Receptor Gene Polymorphisms during Development. Developmental Science, Epub, Jan 11, 2014. PMCID: PMC4069210. PMID: 24410775

2013

Michaelides M., SA Anderson, M Ananth, D Smirnov, PK Thanos, JF Neumaier, GJ Wang, ND Volkow, YL Hurd. In vivo cell-specific mesocorticolimbic whole-brain circuit dissection in freely-moving animals. Journal of Clinical Investigations, 123(12):5342-50, 2013. PMCID: PMC3859392. PMID: 24231358

Anderson SAR, Michaelides M, Zarnegar P, Ren Y, Fagergren P, Thanos PK, Wang G-J, Bannon M, Neumaier JF, Keller E, Volkow ND, Hurd YL. Impaired Periamygdaloid-Cortex Prodynorphin is Characteristic of Opiate Addiction and Depression. Journal of Clinical Investigations, 123(12):5334-41 2013. PMCID: PMC3859405. PMID: 24231353

Karatsoreos I, J Thaler, S Borgland, F Champagne, YL Hurd, and M Hill. Food for Thought: Hormonal, Experiential and Neural Influences on Feeding and Obesity. Journal of Neuroscience, 33(45):17610-6, 2013. PMCID: PMC3818543 PMID: 24198352

Chadwick B, Miller ML, Hurd YL. Cannabis Use during Adolescent Development: Susceptibility to Psychiatric Illness. Front Psychiatry, Oct 14;4:129, 2013. PMCID: PMC3796318. PMID: 24133461

MK Lobo, S Zaman, Rosemary Bagot, D Damez Werno, JW Koo, J DiNieri, A Nugent, E Finkel, E Mouzon, R Cachope, J Cheer, D Dietz, D Self, YL Hurd, V Vialou, and E Nestler. FosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli. J Neuroscience, 33(47):18381-95, 2013. PMCID: PMC3834048. PMID: 24259563

Kozlenkov A, Roussos P. Timashpolsky A, Barbu M, Rudchenko S, Bibikova M, Klotzle B, Byne W, Lyddon R, Di Narzo A, Hurd YL, Koonin E, Dracheva S. Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. Nucleic Acids Research, Epub: Sep 20, 2013. PMCID: PMC3874157. PMID: 24057217

Mitchell AC, Bharadwaj R, Whittle C, Krueger W, Mirnics K, Hurd Y, Rasmussen T, Akbarian S.The Genome in Three Dimensions: A New Frontier in Human Brain Research. Biol Psychiatry. Aug 16, 2013. PMCID: PMC3925763. PMID: 23958183

Hurd YL, Michaelides M, Miller ML, Jutras-Aswad D. Trajectory of Adolescent Cannabis Use on Addiction Vulnerability. Neuropharmacology. Epub: Aug 14, 2013. PMCID: PMC3858398. PMID: 23954491

E Keimpema, A Alpar, F Howell, K Malenczyk, C Hobbs, YL Hurd, M Watanabe, K Sakimura, M Kano, P Doherty and T Harkany. Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling. Nature Scientific Report, 3:2093, 2013. PMCID: PMC3695556. PMID: 23806960

Sillivan SE, Whittard JD, Jacobs MM, Ren Y, Mazloom AR, Caputti F, Horvath M, Keller E, Ma'ayan E, Pan Y-X, Chiang LW and Hurd YL. ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers. Biological Psychiatry, Epub: May 20, 2013. PMCID: PMC4070524. 23702428

Manini AF, Jacobs MM, Vlahov D, Hurd YL. Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population. J Med Toxicol. Jan 15, 2013. Recommended by Faculty of 1000. PMCID: PMC3648633. PMID: 23318993

Bergamaschi MM, Barnes A, Queiroz RH, Hurd YL, Huestis MA. Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine. Anal Bioanal Chem. May;405(14):4679-89, 2013. PMCID: PMC3703206. PMID: 23494274

2012

Jacobs MM, Okvist A, Horvath M, Keller E, Bannon MJ, Morgello S, Hurd YL. Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels. Molecular Psychiatry. Epub Oct 9, 2012. PMCID: PMC3637428. PMID: 23044706

Tomasiewicz HC, Jacobs MM, Wilkinson MB, Wilson SP, Nestler EJ, Hurd YL. Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. Biol Psychiatry. 2012 Nov 15;72(10):803-10. PMID: 22683090.

Jutras-Aswad D, Jacobs MM, Yiannoulos G, Roussos P, Bitsios P, Nomura Y, Liu X, Hurd YL. Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. PLoS One. 2012;7(6):e39243. PMID: 22745721.