neuro
Mobbs Lab
Aging &Metabolism

Selected Publications

2014

Ko F, Isoda F, Mobbs C. Laparotomy in Mice Induces Blood Cell Expression of Inflammatory and Stress Genes. Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research. 2014. doi: 10.1089/jir.2014.0031. PubMed PCMID: 25406893

2013

Mobbs CV, Moreno CL, Poplawski M. Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus. Trends Endocrinol Metab. 2013. doi: 10.1016/j.tem.2013.05.007. PubMed PMID: 23791973; PubMed Central PMCID: 23791973.

Mobbs CV, Moreno C. Hypothalamic EphA5 Facilitates Counterregulatory Responses: Possible Role for Bidirectional Signaling Leading to Bistability That Enhances Responsiveness to Hypoglycemia. Diabetes. 2013;62(4):1014-6. Epub 2013/03/23. doi: 62/4/1014 [pii]10.2337/db12-1735. PubMed PMID: 23520275; PubMed Central PMCID: 3609568.

Kim ES, Isoda F, Kurland I, Mobbs CV. Glucose-induced metabolic memory in Schwann cells: prevention by PPAR agonists. Endocrinology. 2013;154(9):3054-66. doi: 10.1210/en.2013-1097. PubMed Central PMCID: 23709088.

Moreno C, Yang L, Dacks P, Isoda F, Poplawski M, Mobbs CV. Regulation of peripheral metabolism by substrate partitioning in the brain. Endocrinol Metab Clin North Am. 2013;42(1):67-80. doi: 10.1016/j.ecl.2012.11.007. PubMed Central PMCID: 23391240.

Dacks PA, Moreno CL, Kim ES, Marcellino BK, Mobbs CV: Role of the hypothalamus in mediating protective effects of dietary restriction during aging. Front Neuroendocrinol published online, 2013

Kefaloyianni E, Lyssand JS, Moreno C, Delaroche D, Hong M, Fenyo D, Mobbs CV, Neubert TA, Coetzee WA: Comparative proteomic analysis of the ATP-sensitive K(+) channel complex in different tissue types. Proteomics 13:368-378, 2013

Mobbs C, Mastatits J, Isoda F, Poplawski M: Treatment of diabetes and diabetic complications with a ketogenic diet. Journal of Child Neurology (in press), 2013

Mobbs C, Moreno C, Poplawski M: Metabolic mystery: Aging, obesity, diabetes and ventromedial hypothalamus. Trends Endocrinol Metab (in press), 2013

Mobbs CV, Moreno C: Hypothalamic EphA5 facilitates counterregulatory responses: Possible role for bi-directional signaling leading to bi-stability that enhances responsiveness to hypoglycemia. Diabetes (in press), 2013

Moreno C, Yang L, Dacks P, Isoda F, Poplawski M, Mobbs C: Regulation of Peripheral Metabolism by Substrate Partitioning in the Brain. Endocrinol Metab Clin North Am 42:67-80, 2013

2012

Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin BE, McCrimmon R, Sherwin R, Musatov S, Mobbs CV. Hypothalamic Fkbp51 is induced by fasting and elevated hypothalamic expression promotes obese phenotypes. Am J Physiol Endocrinol Metab. 2012. Epub 2012/02/10. doi: ajpendo.00474.2011 [pii] 10.1152/ajpendo.00474.2011. PubMed Central PMCID: 22318949.

Schwartz E, Mobbs CV. Hypothalamic BDNF and obesity: found in translation. Nat Med. 2012;18(4):496-7. Epub 2012/04/07. doi: nm.2716 [pii] 10.1038/nm.2716. PubMed Central PMCID: 22481407.

Dacks PA, Moreno CL, Kim ES, Marcellino BK, Mobbs CV. Role of the hypothalamus in mediating protective effects of dietary restriction during aging. Front Neuroendocrinol. 2012. Epub 2012/12/25. doi: S0091-3022(12)00063-5 [pii]10.1016/j.yfrne.2012.12.001. PubMed Central PMCID: 23262258.

Moreno C, Yang L, Dacks P, Isoda F, Poplawski M, Mobbs CV. Regulation of peripheral metabolism by substrate partitioning in the brain. Endocrinol Metab Clin North Am. 2013;42(1):67-80. doi: 10.1016/j.ecl.2012.11.007. PubMed Central PMCID: 23391240.

Schwartz E, Mobbs CV: Hypothalamic BDNF and obesity: found in translation. Nat Med 18:496-497, 2012

Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin BE, McCrimmon R, Sherwin R, Musatov S, Mobbs CV: Hypothalamic Fkbp51 is induced by fasting and elevated hypothalamic expression promotes obese phenotypes. Am J Physiol Endocrinol Metab, 2012

Mobbs C, Moreno C, Kim E, Ekasumara N, Marcellino B: Neuroprotection by dietary restriction and the Ppar transcription complex. Translational Neuroscience 3:234-241, 2012

2011

Poplawski MM, Mastaitis JW, Mobbs CV. Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia: role of metabolic reprogramming in counterregulatory failure. Diabetes. 2011;60(1):39-46. Epub 2010/09/03. doi: db10-0326 [pii]10.2337/db10-0326. PubMed Central PMCID: 3012195.

Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV. Reversal of diabetic nephropathy by a ketogenic diet. PLoS One. 2011;6(4):e18604. Epub 2011/05/03. doi: 10.1371/journal.pone.0018604. PubMed Central PMCID: 21533091.

Lublin A, Isoda F, Patel H, Yen K, Nguyen L, Hajje D, Schwartz M, Mobbs C. FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity. PLoS One. 2011;6(11):e27762. Epub 2011/11/25. doi: 10.1371/journal.pone.0027762PONE-D-11-16976 [pii].; PubMed Central PMCID: 3218048.

Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med. 2011;17(9):1121-7. Epub 2011/08/30. doi: nm.2421 [pii]10.1038/nm.2421. Central PMCID: 21873987.

2010

Yen K, Mobbs CV. Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordr). 2010;32(1):39-49. Epub 2009/08/08. doi: 10.1007/s11357-009-9110-7. 19662517; PubMed Central PMCID: 2829647.

Poplawski MM, Mastaitis JW, Yang XJ, Mobbs CV. Hypothalamic responses to fasting indicate metabolic reprogramming away from glycolysis toward lipid oxidation. Endocrinology. 2010;151(11):5206-17. Epub 2010/10/01. doi: en.2010-0702 [pii] 10.1210/en.2010-0702. PubMed Central PMCID: 2954726.

Peer - Review Reviewed

Finch CE, Felicio LS, Mobbs CV, Nelson JF. Ovarian and steroidal influences on neuroendocrine aging processes in female rodents. Endocr Rev 1984; 5 (4):467-97.

Mobbs CV. Neurotoxic effects of estrogen, glucose, and glucocorticoids: Neurohumoral hysteresis and its pathological consequences during aging. Reviews of Biological Research on Aging, 1990; 4:201-28.

Mobbs CV, Kaplitt M, Kow LM, Pfaff DW. PLC-alpha: a common mediator of the action of estrogen and other hormones? Mol Cell Endocrinol 1991; 80 (1-3):C187-91.

Mobbs CV. Genetic influences on glucose neurotoxicity, aging, and diabetes: a possible role for glucose hysteresis. Genetica 1993; 91 (1-3):239-53.

Kow LM, Mobbs CV, Pfaff DW. Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: a review. Neurosci Biobehav Rev 1994; 18 (2):251-68.

Mobbs CV. Molecular hysteresis: residual effects of hormones and glucose on genes during aging. Neurobiol Aging 1994; 15 (4):523-34

.Mobbs CV, Bray GA, Atkinson RL, Bartke A, Finch CE, Maratos-Flier E, Crawley JN, Nelson JF. Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span. J Gerontol A Biol Sci Med Sci 2001; 56 Spec No 1:34-44.

Wurmbach E, Gonzalez-Maeso J, Yuen T, Ebersole BJ, Mastaitis JW, Mobbs CV, Sealfon SC. Validated genomic approach to study differentially expressed genes in complex tissues. Neurochem Res 2002; 27 (10):1027-33.

Mizuno TM, Makimura H, Mobbs CV. The physiological function of the agouti-related peptide gene: the control of weight and metabolic rate. Ann Med 2003; 35 (6):425-33.

Holen T, Mobbs CV. Lobotomy of genes: use of RNA interference in Neuroscience. Neuroscience 2004; 126 (1):1-7.

Mizuno T, Shu IW, Makimura H, Mobbs C. Obesity over the life course. Sci Aging Knowledge Environ 2004; 2004 (24):re4.

Mobbs CV. Not wisely but too well: aging as a cost of neuroendocrine activity. Sci Aging Knowledge Environ 2004; 2004 (35):pe33.

Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochem Res 2004; 29 (6):1093-103.

Mobbs CV, Mizuno, T., Isoda, F., Mastaitis, J., Yang, X.J. Impaired glucose signaling as a cause of obesity and the metabolic syndrome: The glucoadipostatic hypothesis Physiol Behav 2005; 85 (1):3-23.

Mobbs CV. Caffeine and the adenosine receptor: Genetics trumps pharmacology in understanding pharmacology. Cellscience 2005; 2:1-6.

Mobbs CV, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M, Isoda F. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: A metabolic mechanism resolving the paradox. Appetite 2007; 48 (2):135-8.

Mobbs CV, Makimura H. Block the FAS, lose the fat. Nat Med 2002; 8 (4):335-6.

Mobbs CV. Fathead: the gain in brain falls mainly with leptin wane. Endocrinology 2006; 147 (2):645-6.

Mobbs CV. The "domino theory" of hunger: the hypothalamus is hot. Cell Metab 2007; 5 (1):1-2.

Chapter in Books

Finch CE, Felicio LS, Flurkey K, Gee DM, Mobbs CV, Nelson JF, Osterberg HH. Studies on ovarian-hypothalamic pituitary interactions during reproductive aging in C57BL/6J mice. Peptides 1980; 1:163-75.

Finch CE, Mobbs CV. Non-lethal measurements involving steroids and neurotransmitters are reflections of physiological aging. In: ME Reff; EL Schneider, editors, translator and editor Proceedings of conference on non-lethal biological markers of physiological aging.; 1981; p. 29-34.

Finch CE, Mobbs CV. Hormonal influences on hypothalamic sensitivity during aging in female rodents. In: J Meites, editor, translator and editor Neuroendocrinology of Aging. New York: Plenum Press; 1983; p. 143-71.

Mobbs CV, Paff DW. Estradiol-regulated neuronal plasticity. In: JF Strauss; DW Pfaff, editors, translator and editor Molecular Neurobiology: Endocrine Approaches. New York: Academic Press; 1987; p. 192-216.

Pfaff DW, Mobbs CV. Some concepts deriving from the neural circuit for a hormone-driving mammalian reproductive behavior. In: H McLennan; JR Ledsome; CHS McIntosh et al., editors, translator and editor Advances in Physiological Research. New York: Plenum Press; 1987; p. 233-51.

Mobbs CV, Pfaff DW. Estrogen-regulated lordosis: Possible roles of uncoating ATPases, enkephalin, and protein kinases. In: AR Genazzi, editor, translator and editor Brain and Female

Reproductive Function. New York: Parthenon Press; 1988; p. 87-100.

Mobbs CV. Neurohumoral hysteresis as a mechanism for senescence; Comparative aspects. In: CG Scanes, and Schriebman, M.P., editor, translator and editor Development, Maturation, and Senescence of the Neuroendocrine System: Academic Press; 1989; p. 223-52.

Pfaff DW, Brooks PJ, Funabashi T, Pfaus JG, Mobbs CV. Gene memory in neuroendocrine and behavioural systems. Ciba Found Symp 1992; 168:165-83.

Mobbs CV. The neuroendocrinology of aging. In, translator and editor Handbook of the Biology of Aging. San Diego: Academic Press; 1996; p. 234-83.

Mobbs CV, and Mizuno, T.M. Leptin effects on POMC. In: E Ur, editor, translator and editor The Neuroendocrinology of Leptin. Basel: Karger; 1998.

Mobbs CV. Leptin and aging. In: CV Mobbs; PR Hof, editors, translator and editor Functional Endocrinology of Aging. Basel: Karger; 1998; p. 228-40.

Mobbs CV. Dehydroepiandesterone and Aging. In: CV Mobbs; PR Hof, editors, translator and editor Functional Endocrinology of Aging. Basel: Karger; 1998; p. 217-27.

Mobbs CV. Reproductive senescence in humans. In: K Knobil; JD Neill, editors, translator and editor Encyclopedia of Reproduction. San Diego: Academic Press; 1999.

Mobbs C, Mizuno T. Leptin regulation of proopiomelanocortin. Front Horm Res 2000; 26:57-70. Mobbs CV. The biology of aging. In: MH Beers; MD Berkow, editors, translator and editor The Merck Manual of Geriatrics. West Point, CA: Merck and Co.; 2000; p. 3-9.

Mobbs CV. Molecular responses to oxidative stress and acidosis. In: G Fink, editor, translator and editor The Encyclopedia of Stress. San Diego: Academic Press; 2000; p. 103-9.

Mizuno TM, Ross A, Mobbs CV. Age-related changes in leptin: consequences and mechanisms. Arch. Geriatrics 2001; 21:234-55.

Mobbs CV. Adaptive capacity. In: GL Maddox, editor, translator and editor Encyclopedia of Aging. New York: Springer; 2001; p. 35-9.

Mobbs CV, Rowe JW. Nature vs nurture in the aging brain. In: PR Hof; CV Mobbs, editors, translator and editor Functional Neurobiology of Aging. San Diego: Academic Press; 2001; p. 13-20.

Mobbs CV. Neuroendocrine theories of aging. In: GL Maddox, editor, translator and editor Encyclopedia of Aging. New York: Springer; 2002; p. 457-81.

Mobbs CV. Molecular and biologic factors in aging. In: CK Cassel, editor, translator and editor Geriatric Medicine. New York: Springer; 2003; p. 15-27.

Mobbs CV. Neurobiology of Aging. In: RC Tallis; HM Fillet, editors, translator and editor Brocklehurst's Textbook of Geriatric Medicine and Gerontology. London: Elseiver; 2003; p. 531-40.

Mobbs CV. Diabetes Insipidus. In: M Aminoff; RB Daroff, editors, translator and editor Encyclopedia of the Neurological Sciences. San Diego: Elsevier; 2003; p. 1-2.

Mobbs CV. Hypoglycemia. In: M Aminoff; RB Daroff, editors, translator and editor Encyclopedia of the Neurological Sciences. San Diego: Elsevier; 2003; p. 616-7.

Mobbs CV. Leptin. In: M Aminoff; RB Daroff, editors, translator and editor Encyclopedia of the Neurological Sciences. San Diego: Elsevier; 2003; p. 780-1.

Mobbs CV. Obesity. In: M Aminoff; RB Daroff, editors, translator and editor Encyclopedia of the Neurological Sciences. San Diego: Elsevier; 2003; p. 649-51.

Mobbs CV. Age-old questions. In: MH Beers; TV Jones, editors, translator and editor The Merck Manual of Health and Aging. Whitehouse Station: Merck and Co.; 2004; p. 1-6.

Yang X-J, Funabashi T, Kow L-M, Mobbs CV. A glucokinase/AP-1 glucose transduction mechanism in the ventromedial hypothalamic satiety center. In: M Magnuson; FM Matschinsky, editors, translator and editor Glucokinase and glycemic disease: From basics to novel therapeutics. Basel: Karger; 2004; p. 313-26.

Mobbs CV. Aging of the brain. In: MS Pathy; AJ Sinclair; JE Morley, editors, translator and editor Principles and Practice of Geriatric Medicine. San Francisco: Wiley; 2006; p. 47-52.

Mobbs CV. Oxidative stress in aging. In: G Fink, editor, translator and editor Encyclopedia of Stress. San Diego: Academic Press; 2007; p. in press.

Mobbs CV. Oxidative stress and acidosis, molecular responses. In: G Fink, editor, translator and editor Encyclopedia of Stress. San Diego: Academic Press; 2007; p. in press.

Mobbs CV, Isoda, F., Mastaitis, J., Yang, X.J., Cheng, H., and Yen, K. Secrets of the lac operon: Glucose hysteresis as a mechanism in aging, dietary restriction, and disease. In: CV Mobbs; K Yen; PR Hof, editors, translator and editor Mechanisms of dietary restriction in aging and disease. Basel: Karger; 2007; p. 39-68.

Books

Mobbs CV, Hof PR. Mechanisms of dietary restriction in aging and disease. Basel: Karger; 2007. 198 p.

Mobbs CV, Hof PR. Functional Endocrinology of Aging. Basel: Karger; 1998. 245 p.

Hof PR, Mobbs CV, editors. Functional neurobiology of aging San Diego, CA: Academic Press; 2001. 1100 p.