The goal of our research is to better understand the molecular mechanisms of addiction and depression. We use animal models of these disorders to identify the ways in which long-term exposure to drugs of abuse or stress changes the brain to lead to addiction- or depression-like syndromes. A major focus of our work is on drug- and stress-induced changes in gene expression and chromatin structure within the brain's reward circuitry.

nestler lab
Laboratory of Molecular Psychiatry

Eric Nestler, MD, PhD
Our lab focuses on transcriptional and epigenetic mechanisms by which drugs of abuse and social stress induce lasting changes in the brain to underlie addiction and depression.
j Neuroscience Sun, H.S., Damez-Werno, D., Scobie, K.N., Shao, N.Y., Dias, C., Rabkin, J., Koo, J.W., Korb, E., Bagot, R.C., Cahill, M., Labonté, B., Mouzon, E., Heller, E.A., Cates, H., Golden, S.A., Gleason, K., Russo, S.J., Andrews, S., Neve, R., Kennedy, P.J., Maze, I., Dietz, D.M., Allis, C.D., Turecki, G., Varga-Weisz, P., Tamminga, C., Shen, L., and Nestler, E.J. (2015) ACF chromatin remodeling complex mediates stress-induced depressive-like behavior. Nat. Med. 21:1146-1153.
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