neuro
nestler lab
Laboratory of Molecular Psychiatry

SELECTED PUBLICATIONS

2013
Chaudhury, D., Walsh, J.J. Friedman, A.K., Juarez, B., Ku, S.M., Koo, J.W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D.J., Nextow, A.R., Ekstrand, M., Domingos, A., Mazie-Robison, M., Mouzon, E., Lobo, M.K., Neve, R.L., Friedman, J.M., Russo, S.J., Deisseroth, K., Nestler, E.J., and Han, M.-H. (2012) Rapid regulation of depression-related behaviors by control of midbrain dopamine neurons. Nature 493:532-536.

2012
Dietz, D.M., Sun, H.S., Lobo, M.K., Cahill, M.E., Chadwick, B., Gao, V., Koo, J.W., Mazei-Robison, M.S., Dias, C., Maze, I., Damez-Werno, D., Dietz, K.C., Scobie, K.N., Ferguson, D., Christofell, D., Ohnishi, Y., Hodes, G.E., Zheng, Y., Neve, R.L., Hahn, K.M., Russo, S.J., and Nestler, E.J. (2012) Essential for Rac1 in cocaine-induced structure plasticity of nucleus accumbens neurons. Nature Neurosci. 15:891-896.
Koo, J.W., Mazei-Robison, M.S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H.S., Scobie, K.N., Damez-Werno, D., Crumiller, M., Ohnishi, Y.N., Ohnishi, Y.H., Mouzon, E., Dietz, D.M., Lobo, M.K., Neve, R.L., Russo, S.J., Han, M.H., and Nestler, E.J. (2012) BDNF is a negative modulator of morphine action. Science 338:124-128.
 

Vialou, V., Feng, J., Robison, A.J., and Nestler, E.J. (2012) Epigenetic mechanisms of depression and antidepressant action. Annu. Rev. Pharmacol. Toxicol. 53:59-87.
Russo, S.J., Murrough, J.W., Han, M.H., Charney, D.S., and Nestler, E.J. (2012) Neurobiology of resilience. Nature Neurosci. 15:1475-1484.

2011
Covington, H.E. III, Maze, I., Sun, H.S., Wu, E.Y., Dietz, D., Lobo, M.K., Ghose, S., Neve, R., Tamminga, C.A., and Nestler, E.J. (2011) A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 71:656-670.

Dietz, D.M., LaPlant, Q., Watts, E.L., Hodes, G.E., Russo, S.J., Feng, J., Oosting, R.S., and Nestler, E.J. (2011) Paternal transmission of stress-induced pathologies. Biol. Psychiatry 70:408-414.

Mazei-Robison, M.S., Koo, J.W., Friedman, A., Lansink, C.S., Robison, A.J., Vinish, M., Krishnan, V., Kim, S., Siuta, M.A., Galli, M.A., Niswender, K.D., Appasani, R., Horvath, M.C., Neve, R.L., Worley, P.F., Snyder, S.H., Hurd, Y.L., Cheer, J.F., Han, M.H., Russo, S.J., and Nestler, E.J. (2011) Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 72:977-990.
Robison, A.J. and Nestler, E.J. (2011) Transcriptional and epigenetic mechanisms of addiction. Nature Rev. Neurosci. 12:623-637.
  Nestler EJ (2011) Hidden switches in the mind. Scientific American, Dec 2011, pp. 76-83.
Maze, I., Feng, J., Wilkinson, M.B., Sun, H.S., Shen, L., and Nestler, E.J. (2011) Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc. Natl. Acad. Sci. USA 108:3035-3040.

2010
Russo, S.J., Dietz, D.M., Dumitriu, D., Morrison, J.H., Malenka, R.C., and Nestler, E.J. (2010) The addicted synapse:  Mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci. 33:267-276.
Lobo, M.K., Covington, H.E. III, Chaudhury, D., Friedman, A.K., Sun, H.S., Damez-Werno, D., Dietz, D., Zaman, S., Koo, J.W., Kennedy, P.J., Mouzon, E., Mogri, M., Neve, R.L., Deisseroth, K., Han, M.H., and Nestler, E.J. (2010) Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390.
Maze, I., Covington, H.E. III, Dietz, D.M., LaPlant, Q., Renthal, W., Russo, S.J., Mechanic, M., Mouzon, E., Neve, R.L., Haggarty, S.J., Ren, Y.H., Sampath, S.C., Hurd, Y.L., Greengard, P., Tarakovsky, A., Schaefer, A., and Nestler, E.J. (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327:213-216.

2009
Renthal, W., Kumar, A., Xiao, G.H., Wilkinson, M., Convington, H.E. III, Mze, I., Sikder, D., Robison, A.J., LaPlant, Q., Dietz, D.M., Russo, S.J., Vialou, V., Chakravarty, S., Kodadek, T.J., Stack, A., Kabbaj, M., and Nestler, E.J. (2009) Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins. Neuron 62:335-348.
Wallace, D.L., Han, M.H., Graham, D.L., Green, T.A., Vialou, V., Iniguez, S.D., Cao, J.L., Chakravarty, S., Kumar, A., Krishnan, V., Neve, R.L., Cooper, D.C., Bolaños, C.A., Barrot, M., McClung, C.A., and Nestler, E.J. (2009) CREB Regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nature Neurosci. 12:200-209.

2008
Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S.A., Anderson, J.G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J.K., Nestler, E.J., and Zigman, J.M. (2008) The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nature Neurosci. 11:752-753.
Pulipparacharuvil, S., Renthal, W., Hale, C.F., Taniguchi, M., Xiao, G.H., Kumar, A., Russo, S.J., Sikder, D., Dewey, C.M., Davis, M.M., Greengard, P., Nairn, A.C., Nestler, E.J., and Cowan, C.W. (2008) Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59:621-633.
Krishnan, V. and Nestler, E.J. (2008) The molecular neurobiology of depression. Nature 455:894-902.

2007
Russo, S.J., Bolanos, C.A., Theobald, D.E., DeCarolis, N.A., Renthal, W.R., Kumar, A., Winstanley, C.A., Renthal, N.E., Wiley, M.D., Self, D.W., Russell, D.S., Neve, R.L., Eisch, A.J., and Nestler, E.J. (2007) The IRS2-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates. Nature Neurosci. 10:93-99.
Tsankova, N., Renthal, W., Kumar, A., and Nestler, E.J. (2007) Epigenetic regulation in psychiatric disorders. Nature Rev. Neurosci. 8:355-367.
Krishnan, V., Han, M.-H., Graham, D.L., Berton, O., Renthal, W., Russo, S.J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D.C., Ghose, S., Reister, R., Tannous, P., Green, T.A., Neve, R.L., Chakravarty, S., Kumar, A., Eisch, A.J., Self, D.W., Lee, F.S., Tamminga, C.A., Cooper, D.C., Gershenfeld, H.K., and Nestler, E.J. (2007) Susceptibility and resistance to social defeat are mediated through molecular adaptations in brain reward regions. Cell 131:391-404.
Renthal, W., Maze, I., Krishnan, V., Covington, H.E., Xiao, G.H., Kumar, A., Russo, S.J., Graham, A., Tsankova, N., Kerstetter, K.A., Kippin, T.E., Neve, R.L., Haggarty, S.J., McKinsey, T.A., Bassel-Duby, R., Olson, E.N., and Nestler, E.J. (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56:517-529.

2006
Berton, O., McClung, C.A., DiLeone, R.J., Krishnan, V., Russo, S., Graham, D., Tsankova, N.M., Bolanos, C.A., Rios, M., Monteggia, L.M., Self, D.W., and Nestler, E.J. (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868.
Zachariou, V., Bolanos, C.A., Selley, D.E., Theobald, D., Cassidy, M.P., Kelz, M.B., Shaw-Lutchmann, T., Berton, O., Sim-Selley, L.J., DiLeone, R.J., Kumar, A., and Nestler, E.J. (2005) ΔFosB: An essential role for ΔFosB in the nucleus accumbens in morphine action. Nature Neurosci. 9:205-211.
Tsankova, N.M., Berton, O., Renthal, W., Kumar, A., Neve, R.L., and Nestler, E.J. (2006) Sustained chromatin regulation in hippocampus in a mouse model of depression and antidepressant action: A novel role for HDAC5. Nature Neurosci. 9:519-525.

2005
McClung, C.A., Sidiropoulou, K., Vitaterna, M., Takahashi, J.S., White, F.J., Cooper, D.C., and Nestler, E.J. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc. Natl. Acad. Sci. USA 102:9377-9381.
Nestler, E.J. (2005) Is there a common molecular pathway for addiction. Nature Neurosci. 8:1445-1449
Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N.M., Theobald, D.E.H., Truong, H.-T., Russo, S.J., LaPlant, Q., Whistler, K., Neve, R.L., Self, D.W., and Nestler, E.J. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48:303-314.
Berton, O. and Nestler, E.J. (2005) New approaches to antidepressant drug discovery: Beyond monoamines. Nature Rev. Neurosci. 7:137-151.

2004
Nestler, E.J. and Malenka, R.C. (2004) The addiction brain. Scientific American, March 2004, pp. 78-85.
Monteggia, L.M., Barrot, M., Powell, C.M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R.W., and Nestler, E.J. (2004) Essential role of BDNF in adult hippocampal function. Proc. Natl. Acad. Sci. USA 101:10827-10832.

2003
McClung, C.A. and Nestler, E.J. (2003) Regulation of gene expression and cocaine reward by CREB and ΔFosB. Nature Neurosci. 6(11):1208-1215.
Zachariou, V., Georgescu, D., Sanchez, N., Rahman, Z., DiLeone, R., Berton, O., Simon, M., Neve, R.L., Sim-Selley, L.J., Selley, D.E., Gold, S.J., and Nestler, E.J. (2003) Essential role for RGS9 in opiate action. Proc. Natl. Acad. Sci. USA 100:13656-13661.
Rahman, Z., Schwarz, J., Zachariou, V., Gold, S.J., Wein, M., Choi, K.H., et al. (2003) RGS9 modulates dopamine signaling in striatum. Neuron, 38:941-952.

2002
Barrot, M., Olivier, J.D.A., Perrotti, L.I., Impey, S., Storm, D.R,, Neve, R.L., Zachariou, V., & Nestler, E.J. (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA 99:11435-11440.
Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J., and Monteggia, L.M. (2002) Neurobiology of depression. Neuron 34:13-25.

2001
Nestler, E.J. (2001) Molecular basis of neural plasticity underlying addiction. Nature Rev. Neurosci. 2:119-128.

1999
  Kelz, M.B., Chen, J.S., Carlezon, W.A., Whisler, K., Gilden, L., Beckmann, A.M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D.W., Tkatch, R., Baranauskas, G., Surmeier, D.J., Neve, R.L., Duman, R.S., Picciotto, M.R., and Nestler, E.J. (1999) Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 401:272-276.

1998
Carlezon, W.A., Jr., Thome, J., Olson, V.G., Lane-Ladd, S.B., Brodkin, E.S., Hiroi, N., Duman, R.S., Neve, R.L., and Nestler, E.J. (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275.

1997
Carlezon, W.A., Jr., Boundy, V.A., Haile, C.N., Kalb, R.G., Neve, R., and Nestler, E.J. (1997) Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814.
Nestler, E.J. and Aghajanian, G.K. (1997) Molecular and cellular basis of addiction. Science 278:58-63.

1996
Self, D.W., Barnhart, W.J., Lehman, D.A., and Nestler, E.J. (1996) Opposite modulation of cocaine-seeking behavior by D1-like and D2-like dopamine receptor agonists. Science 271:1586-1589.

1994
Hope, B.T., Nye, H.E., Kelz, M.B., Self, D.W., Iadarola, M.J., Nakabeppu, Y., Duman, R.S., and Nestler, E.J. (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235-1244.

1993
Nestler, E.J., Hope, B.T., and Widnell, K.L. (1993) Drug addiction: A model for the molecular basis of neural plasticity. Neuron 11:995-1006.

BOOKS
  Nestler, E.J. and Greengard, P. (1984) Protein Phosphorylation in the Nervous System, J. Wiley & Sons, New York.
Hyman, S.E. and Nestler, E.J. (1993) The Molecular Foundations of Psychiatry, American Psychiatric Press, Washington, D.C.
  Goldstein, A. and Nestler, E.J. (Eds.) (1998) Special Issue: Neurobiology of Addiction. Drug and Alcohol Dependence, vol. 51, numbers 1 and 2.
Charney, D.S. and Nestler, E.J. (Eds.) (2009) Neurobiology of Mental Illness, 3rd Ed., Oxford University Press, New York. (1st edition published in 1999, 2nd ed. in 2003.)
Nestler, E.J., Hyman, S.E., and Malenka, R.C (2009) Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 2nd Ed., McGraw-Hill, New York. (1st edition published in 2001.)
Rosenberg, R.N., DiMauro, S., Paulson, H.L., Ptacek, L., and Nestler, E.J. (Eds.) (2008) The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 4th Ed, Lippincott, Williams and Wilkins, New York. (3rd edition published in 2003.)
   
Nestler Laboratory
Lab Location: ICAHN 10-26
Office Location: ICAHN 10-23a

Office: (212) 659 - 5996
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