About the Program

Addiction remains one of the world’s greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. We believe that the most effective way of eventually developing definitive treatments and cures for addiction rests in part in a better understanding of its underlying neurobiology.
Read more about drug addiction.

The objective of this Program Project Grant (PPG) is to fundamentally advance our understanding of the molecular and cellular mechanisms that underlie stimulant and opiate addiction. We focus on the brain's reward regions, in particular, the midbrain ventral tegmental area (VTA) and several of its forebrain projection regions, including the nucleus accumbens (NAc) and prefrontal cortex (PFC). We utilize a wide range of cutting-edge technologies to explicate the molecular, cellular, and circuit basis of addiction, including a focus on chromatin biology, so-called epigenetics, as well as advanced neurophysiological methods, state-of-the-art optogenetic tools, and sophisticated animal models of addiction. Importantly, our PPG has a strong translational component in that we validate key findings from animal models in homologous brain regions of addicted humans examined postmortem. In turn, new insight from studies of human brain feeds back andinforms our animal research to explore the underlying molecular and cellular mechanisms involved. 

The PPG is composed of two Scientific Cores and four Projects:

Transgenic-Molecular Core
(PI, Eric Nestler, Mount Sinai School of Medicine)

Behavioral Core (PI, Vanna Zachariou, Mount Sinai School of Medicine)

Project 1: Role of CREB in Opiate and Cocaine Addiction (PI, Eric Nestler, Mount Sinai School of Medicine)

Project 2: Cellular Studies of Drug Action (PI, Rob Malenka, Stanford University)

Project 3: Chromatin and Gene Regulation in Drug Addiction (PI, Eric Nestler, Mount Sinai School of Medicine)

Project 4: Neurobiology of Drug Reward and Relapse (PI, David Self, UT Southwestern Medical Center at Dallas)

For further information please contact the digital-media-center@mssm.edu