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Many neurodegenerative disorders arise in part due to defects in neuronal intracellular transport.  Neuronal intracellular transport through the endoplasmic reticulum and endolysosomal system appears to be most vulnerable to environmental or genetic insults.  In the long term, we want to understand the proteins, molecular pathways and cellular processes that are the loci of vulnerability in these disorders.  We are studying a class of putative adhesion/recognition molecules termed the clustered protocadherins (Pcdhs).  We suspect that the Pcdhs participate in an as yet unidentified trafficking pathway related to the endolysosomal system in addition to their ability to mediate cell-cell interactions at synapses.


Greg Phillips, PhD
Intracellular trafficking in neurons is tied to synapse development and neurodegenerative disorders. We are interested in understanding the molecules and cellular mechanisms vulnerable to disruption.
journal of neuroscience Fernandez-Monreal, M., Oung, T., Hanson, H.H., O'Leary, R., Janssen, W.G., Dollos, G., Wang, R., and Phillips, G.R. (2010) Gamma-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons. Eur J Neurosci. 32:921-31.
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