Research in our laboratory focuses on mechanisms underlying the regulation of gene expression and how these mechanisms are disrupted in neurodegenerative diseases. We use high-throughput functional genomics and genetic association studies to identify regions of the genome with functional effects on tissues and cells of the brain. We apply methods from statistical and population genetics to large-scale genotyping and sequencing studies to discover novel susceptibility alleles for age-related cognitive decline and Alzheimer's disease. We collaborate extensively with colleagues to develop and apply methods for constructing causal regulatory networks to understand mechanisms driving complex diseases. Our work is primarily computational, with an emphasis on integrative data analysis and the development of statistical and computational approaches, but we often work closely with experimental biologists.
Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM, Lang R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA; Alzheimer Disease Genetics Consortium. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement. 2015 Jun 16. pii: S1552-5260(15)00190-9. PMID: 26092349.