A major focus of my research is to study the neural and immunological mechanisms of neuropsychiatric disorders such as depression and anxiety. We use a combination of transgenic mice, immune cell transplantation, optogenetics/electrophysiology, viral mediated gene transfer, behavioral models and molecular methods to understand how the brain and body adapts to stress to control pathological behaviors in depression and anxiety.
Golden SA, Christoffel DJ, Heshmati M, Magida J, Hodes GE, Davis K, Cahill M, Dias C, Ribero E, Ables JL, Maeso-Gonzalez J, Neve RL, Ghose S, Tamminga CA, and Russo SJ. Epigenetic regulation of synaptic remodeling in depression. Nature Medicine. 2013 Mar 19;110(12):4441-2.
Hodes GE, Pfau ML, Leboeuf M, Golden SA, Christoffe DJ, Bregman D, Rebusi N, Heshmati M, Aleyasin H, Warren BL, Lebonté B, Horn S, Lapidus KA, Stelzhammer V, Wong EHF, Bahn S, Krishnan V, Bolaños-Guzman CA, Murrough JW, Merad M, Russo SJ "Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress, Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16136-41.
Christoffel DJ, Walsh JJ, Golden SA, Heshmati M, Friedman AK, Dey A, Smith M, Rebusi N, Pfau M, Ables JL, Hodes GE, Deisseroth K, Ibanez-Tallon I, Han MH, Russo SJ. Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress. Nat Neurosci, 2015 Jul;18(7):962-4.
Dr. Scott J. Russo is an Associated Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. He obtained his Ph.D. in Psychology from the City University of New York Graduate School and University Center and then completed his postdoctoral work in Psychiatry and Psychology at the University of Texas Southwestern Medical Center.
Johnson & Johnson / IMHRO Rising Star Translational Research Award winner, explains his lab's discoveries connecting depressionwith the immune system, suggesting a new physiological avenue for research into more effective depression therapies. For the 30% of depression sufferers who do not respond to conventional brain-centric medications, this could be very big. Recorded at IMHRO's Music Festival for Mental Health 2012.
Depression might be an allergic reaction to stress.
Georgia Hodes, PhD, talks with Anna Maria Tremonti on The Current.