A major focus of my research is to study the neural and immunological mechanisms of neuropsychiatric disorders such as depression and anxiety. We use a combination of transgenic mice, immune cell transplantation, optogenetics/electrophysiology, viral mediated gene transfer, behavioral models and molecular methods to understand how the brain and body adapts to stress to control pathological behaviors in depression and anxiety.
Golden SA, Heshmati M, Flanigan M, Christoffel DJ, Guise K, Pfau ML, Aleyasin H, Menard C, Zhang H, Hodes GE, Bregman D, Khibnik L, Tai J, Rebusi N, Krawitz B, Chaudhury D, Walsh JJ, Han MH, Shapiro ML, Russo SJ. Basal forebrain projections to the lateral habenula modulate aggression reward. Nature. 2016 Jun 29;534(7609):688-92.
Hodes GE, Pfau ML, Leboeuf M, Golden SA, Christoffe DJ, Bregman D, Rebusi N, Heshmati M, Aleyasin H, Warren BL, Lebonté B, Horn S, Lapidus KA, Stelzhammer V, Wong EHF, Bahn S, Krishnan V, Bolaños-Guzman CA, Murrough JW, Merad M, Russo SJ "Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress, Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16136-41.
Christoffel DJ, Walsh JJ, Golden SA, Heshmati M, Friedman AK, Dey A, Smith M, Rebusi N, Pfau M, Ables JL, Hodes GE, Deisseroth K, Ibanez-Tallon I, Han MH, Russo SJ. Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress. Nat Neurosci, 2015 Jul;18(7):962-4.
Dr. Scott J. Russo is an Associate Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. He obtained his Ph.D. in Psychology from the City University of New York Graduate School and University Center and then completed his postdoctoral work in Psychiatry and Psychology at the University of Texas Southwestern Medical Center.
New Research Shows Bullying Impacts The Reward Center Of The Brain — July 5, 2016
A new study shows that the reward center of the brain is active when a person is bullying someone. We'll learn about the research from Dr. Scott Russo, Associate Professor of Neuroscience at the Icahn School of Medicine at Mt. Sinai Hospital.
Gender Differences in the Stressed-Out Brain — April 14, 2016
Press an American to explain the differences between men and women and you will get a whole gamut of answers. They might say women are more emotional. Or, they might say the only fundamental differences are reproductive organs and hormones, that everything else is a product of social expectations (i.e. nurture over nature). Read more.
Johnson & Johnson / IMHRO Rising Star Translational Research Award winner, explains his lab's discoveries connecting depressionwith the immune system, suggesting a new physiological avenue for research into more effective depression therapies. For the 30% of depression sufferers who do not respond to conventional brain-centric medications, this could be very big. Recorded at IMHRO's Music Festival for Mental Health 2012.