neuro
Russo lab
Laboratory of Neural and Immune Mechanisms of Psychiatric Illness

Selected Publications

2016

Golden SA, Heshmati M, Flanigan M, Christoffel DJ, Guise K, Pfau ML, Aleyasin H, Menard C, Zhang H, Hodes GE, Bregman D, Khibnik L, Tai J, Rebusi N, Krawitz B, Chaudhury D, Walsh JJ, Han MH, Shapiro ML, Russo SJ. Basal forebrain projections to the lateral habenula modulate aggression reward. Nature. 2016 Jun 29;534(7609):688-92. doi: 10.1038/nature18601.

2015

Nugent BM, Wright CL, Shetty AC, Hodes GE, Lenz KM, Mahurkar A, Russo SJ, Devine SE, McCarthy MM. Brain feminization requires active repression of masculinization via DNA methylation. Nat Neurosci. 2015 May;18(5):690-7.

Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Peña CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonté B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci. 2015 Mar;18(3):415-22.

Christoffel DJ, Walsh JJ, Golden SA, Heshmati M, Friedman AK, Dey A, Smith M, Rebusi N, Pfau M, Ables JL, Hodes GE, Deisseroth K, Ibanez-Tallon I, Han MH, Russo SJ. Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress. Nat Neurosci, 2015.

Khibnik LA, Beaumont M, Doyle M, Heshmati M, Slesinger PA, Nestler EJ, Russo SJ. Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens. Biol Psychiatry, 2015 Jun 6. pii: S0006-3223(15)00471-0.

Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Koo JW, Korb E, Bagot RC, Ahn FH, Cahill ME, Labonté B, Mouzon E, Heller EA, Cates H, Golden SA, Gleason K, Russo SJ, Andrews S, Neve R, Kennedy PJ, Maze I, Dietz DM, Allis CD, Turecki G, Varga-Weisz P, Tamminga C, Shen L, Nestler EJ. ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior. Nat Med. 2015 Oct;21(10):1146-53.

Birey F, Kloc M, Chavali M, Hussein I, Wilson M, Christoffel DJ, Chen T, Frohman MA, Robinson JK, Russo SJ, Maffei A, Aguirre A. Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive- like Behaviors through Reduced Secretion of FGF2. Neuron. 2015 Dec 2;88(5):941-56.

Hodes GE, Pfau ML, Purushothaman I, Ahn HF, Golden SA, Christoffel DJ, Menard CA, Magida J, Aleyasin H, Koo JW, Lorsch ZS, Feng J, Heshmati M, Wang M, Turecki G, Neve R, Zhang B, Shen L, Nestler EJ, Russo SJ. Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to sub-chronic variable stress. J Neurosci. 2015 Dec 16;35(50):16362-76.

2014

Hodes GE, Pfau ML, Leboeuf M, Golden SA, Christoffe DJ, Bregman D, Rebusi N, Heshmati M, Aleyasin H, Warren BL, Lebonté B, Horn S, Lapidus KA, Stelzhammer V, Wong EHF, Bahn S, Krishnan V, Bolaños-Guzman CA, Murrough JW, Merad M, Russo SJ "Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress, Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16136-41.

2013

Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison MS, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature. 2013 Jan 24;493(7433):532-6.

Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J. Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System. J Neurosci. 2013 Jan 16;33(3):1088-98.

Golden SA, Christoffel DJ, Heshmati M, Magida J, Hodes GE, Davis K, Cahill M, Dias C, Ribero E, Ables JL, Maeso-Gonzalez J, Neve RL, Ghose S, Tamminga CA, and Russo SJ. Epigenetic regulation of synaptic remodeling in depression. Nature Medicine. 2013 Mar 19;110(12):4441-2.

Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison MS, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman JM, Russo SJ, Nestler EJ, Han MH. Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nat Neurosci. Jan;17(1):27-9.

2012

Dietz DM, Sun H, Lobo MK, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison MS, Dias C, Maze I, Damez-Werno D, Dietz KC, Scobie KN, Ferguson D, Christoffel D, Ohnishi Y, Hodes GE, Zheng Y, Neve RL, Hahn KM, Russo SJ, Nestler EJ. Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci. 2012 Jun;15(6):891-6.

Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012 Sep;15(9):1245-54.

Christoffel DJ, Golden SA, Heshmati M, Graham A, Birnbaum S, Neve RL, Hodes G and Russo SJ. Effects of Inhibitor of kB Kinase Activity in the Nucleus Accumbens on Emotional Behavior. Neuropyschopharmacology. 2012 Nov;37(12):2615-23.

Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, and Nestler EJ, Novel Role of BDNF as a Negative Modulator of Morphine Action. Science 2012 Oct 5;338(6103):124-8.

2011

Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes C, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, and Russo SJ. IkappaB kinase regulates social defeat stress induced synaptic and behavioral plasticity. J Neurosci. 2011 Jan 5;31(1):314-21. "Must Read" in F1000.

Dietz DM, Laplant Q, Watts EL, Hodes GE, Russo SJ, Feng J, Oosting RS, Vialou V, Nestler EJ. Paternal transmission of stress-induced pathologies. Biol Psychiatry. 2011. Golden SA, Covington HE, Berton O, and Russo SJ. Repeated social defeat stress in mice: a high throughput protocol. Nat Protocol. 2011 Aug 6(8): 1183-1191.

Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli A, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ, Nestler EJ. Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons. Neuron. 2011 Dec 22;72(6):977-90.

2010

Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E , Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ. Essential Role of the Histone Methyltransferase G9a in Cocaine-induced Plasticity. Science, 2010 327(5962):213-6.

Koo JW, Russo SJ, Ferguson D, Nestler EJ, and Duman RS. Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior. PNAS. 2010 107(6):2669-74. "Recommended" in F1000.

2009

LaPlant Q, Chakravarty S, Vialou V, Mukherjee S, Koo JW, Kalahasti G, Bradbury KR, Taylor SV, Maze I, Kumar A, Graham A, Birnbaum SG, Krishnan V, Truong HT, Neve RL, Nestler EJ, Russo SJ: Role of NFκB in ovarian hormone mediated stress hypersensitivity in female mice. Biol Psychiatry, 2009 May 15;65(10):874-80.

Russo SJ, Wilkinson MB, Mazei-Robison M, Dietz DM, Maze I, Krishnan V, Renthal W, , Renthal W, Graham A, Birnbaum SG, Green TA, Robison B, Lesselyong A, Perrotti LI, Bolanos CA, Kumar A, Clark MS, Neumaier JF, Neve RL, Bhakar AL, Barker PA, Nestler EJ. Nuclear Factor κB signaling regulates neuronal morphology and cocaine reward. J Neurosci 2009 29(11): 3529- 3537.

Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE III, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Kabbaj M, Nestler EJ. Genome Wide Promoter analysis of chromatin regulation by cocaine. Neuron 2009 May 14;62(3):335-48. . "Must Read" in F1000.

2008

Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW. Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity. Neuron Aug 28;59(4):621-33. "Must Read" in F1000.

2007

Russo SJ, Bolaños CA, Theobald DE, DeCarolis NA, Renthal W, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell D, Neve RL, Eisch AJ, Nestler EJ: IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci. 2007 Jan; 10(1):93-9.

For news and views see: Harvey BK, Hope BT, Shaham Y: Tolerance to opiate reward: role of midbrain IRS2-Akt pathway. Nat Neurosci. 2007 Jan; 10(1):9-10. "Recommended" in F1000.

Roybal K, Theobald D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Kumar A, Peevey J, Oehrlein N, Birnbaum S, Vitaterna M, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr; 10(15):6406-11. "Recommended" in F1000.

Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Eisch AJ, Self DW, Lee FS, Tamminga C, Cooper DC, Gershenfeld HK, Nestler EJ Molecular Mechanisms Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions. 2007 Cell. Oct 19;131(2):391-404. . "Must Read" in F1000.

Renthal W, Maze I, Krishnan V, Covington HE, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN Nestler EJ. Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli. 2007 Neuron. Nov 8;56(3):517-29.

Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW. Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity. Neuron Aug 28;59(4):621-33. "Must Read" in F1000.

2006

Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M et al: Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006, 311(5762):864-868. "Exceptional" in F1000.

2005

Kumar A, Choi KH, Renthal W, Tsankova NM, Theobald DE, Truong HT, Russo SJ, Laplant Q, Sasaki TS, Whistler KN et al: Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 2005, 48(2):303-314.

Reviews and commentaries

Hodes GE, Kana V, Menard C, Merad M, Russo SJ. Neuroimmune mechanisms of depression. Nat Neurosci. In press.

Russo SJ, Nestler EJ. Brain reward circuitry in mood disorders. Nature Reviews Neuroscience. 2013 Sep;14(9):609-25.

Russo SJ, Charney DS. Next generation antidepressants. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4441-2.

Russo SJ, Murrough J, Han MH, Charney DS, Nestler EJ. Neurobiology of resilience. Nature Neuroscience. 2012 Nov;15(11):1475-84.

Golden SA, Russo SJ. Mechanisms of psychostimulant induced structural plasticity. Cold Spring Harbor Perspectives in Medicine. 2012 Oct 1;2(10).

Christoffel DJ, Golden SA, Russo SJ. Structural and synaptic plasticity in stress-related disorders. Rev Neurosci. 2011;22(5):535-49.

Russo SJ, Dietz DM, Dumitriu D, Morrison JH, Malenka RC, Nestler EJ. The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci. 2010 Jun;33(6):267-76.