salton lab
Neurotrophin Actions in CNS and PNS



Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice. Foglesong GD, Huang W, Liu X, Slater AM, Siu J, Yildiz V, Salton SR, Cao L. Endocrinology. 2016 Mar;157(3):983-96. PMID: 26730934


VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism. Lin WJ, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Alberini CM, Salton S.R. J. Neurosci. 2015 Jul 15;35(28):10343-56. PMID: 26180209.

Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of "humanized" knockin mice expressing full-length or truncated VGF. Sadahiro M, Erickson C, Lin WJ, Shin AC, Razzoli M, Jiang C, Fargali S, Gurney A, Kelley KA, Buettner C, Bartolomucci A, Salton SR. Endocrinology. 2015 May;156(5):1724-38. doi: 10.1210/en.2014-1826. Epub 2015 Feb 12. PMID: 25675362.


Fairbanks, C.A., Peterson, C.D., Speltz, R.H., Riedl, M.S., Kitto, K.F., Dykstra, J.A., Braun, P.D., Sadahiro, M., Salton, S.R., Vulchanova, L. (2014). The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury induced hypersensitivity. Pain 155(7):1229-1237.

Fargali, S., Garcia, A., Sadahiro, M., Jiang, C., Janssen, W.G., Lin, W.J., Cogliani, V., Elste, A., Mortillo, S., Cero, C., Veitenheimer, B., Graiani, G., Pasinetti, G.M., Mahata, S.K., Osborn, J.W., Huntley, G.W., Phillips, G.R., Benson, D.L., Bartolomucci, A., Salton, S.R. (2014). The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J 28(5):2120-2133.


Jiang, C. and Salton, S.R. (2013). The role of neurotrophins in major depressive disorder. Transl. Neurosci. 4:46-58.

Lin, W.J. and Salton, S.R. (2013). The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms. Front. Endocrinol. 4:96.


Boersma, G.J., Salton, S.R., Spritzer, P.M., Steele, C., Carbone, D.L. (2012). Models and mechanisms of metabolic regulation: Genes, stress and the HPA and HPG axes. Horm. Metab. Res. 44:598-606.

Fargali, S., Sadahiro, M., Jiang, C., Frick, A.L., Indall, T., Cogliani, V., Welagen, J., Lin, W.J., Salton, S.R. (2012). Role of neurotrophins in the development and function of neural circuits that regulate energy homeostasis. J. Mol. Neurosci. 48:654-659.

Fargali, S., Scherer, T., Shin, A.C., Sadahiro, M., Buettner, C., Salton, S.R. (2012). Germline ablation of VGF increases lipolysis in white adipose tissue. J. Endocrinol. 215:313-322.


Sepulveda, B., Carcea, I., Zhao, B., Salton, S.R.J., Benson, D.L. (2011). Ethanol inhibits and L1CAM preserves cortical axon responses to guidance cues. Neuroscience, 180:30-40.

Bartolomucci, A., Fischer-Colbrie, R., Mahata, S, Possenti, R., Loh, Y.P., Salton, S.R.J. (2011). The extended granin family: structure, function and biomedical implications. Endocr. Rev. 32:755-797.


Bartolomucci, A., Pasinetti, G.M., Salton, S.R.J. (2010) Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders. Neuroscience 170:289-297.

Carcea, I., Ma'ayan, A., Mesias, R., Sepulveda, B, Salton, S.R., Benson, D.L. (2010) Flotillin-mediated endocytic events dictate cell-type specific responses to Semaphorin 3A. J Neurosci 30:15317-15329.


Watson E., Fargali, S., Okamoto, H., Sadahiro, M., Gordon, R.E., Chakraborty, T., Sleeman, M.W., Salton, S.R. (2009). Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure. BMC Physiology 9:19.


Zhao, Z., Lange, D., Ho, L., Bonini, S., Shao, B., Salton, S.R., Thomas, S., Pasinetti, G.M. (2008). VGF is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis.  Int. J. Med. Sci., 5:92-99.

Sakurai, T., Gil, O.G., Whittard, J.D., Gazdoiu, M., Joseph, T., Wu, J., Waksman, A., Benson, D.L., Salton, S.R., Felsenfeld, D.P. (2008).  Interactions between L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation.  J. Neurosci. Res. 86:2602-2614.

Chakraborty, S., Sachdev, A., Salton, S.R., Chakraborty, T. (2008).  Stereological analysis of estrogen receptor expression in the hypothalamic arcuate nucleus of ob/ob and agouti mice.  Brain Res. 1217:86-95.

Hoffman, E.J., Mintz, C.D., Wang, S., McNickle, D.G., Salton, S.R., Benson, D.L. (2008).  Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons.  Neuroscience 157:556-565.

Moss, A., Theodorou, A., Low, L., Ingram, R., Kock, S., Baccei, M., Hathway, G.J., Costigan, M., Salton, S.R., Fitgerald, M. (2008) Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurons following peripheral nerve injury. Mol Pain 4:62.

Bozdagi, O., Rich, E., Tronel, S., Sadahiro, M., Patterson, K., Shapiro, M.L., Alberini, C., Huntley, G.W., Salton, S.R. (2008) The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a BDNF-dependent mechanism. J Neurosci 28: 9857-9869.

Mintz, C.D., Carcea, I., Burke, M.E., McNickle, D.G., Ge, Y.C., Dickson, T.C., Salton, S.R., Benson, D.L. (2008) ERM proteins regulate response and adaptation to Sema3A. J Comp Neurol 510:351-366.


Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS. Novel antidepressant actions of the exercise-regulated gene VGF. (2007) Nat Med 13:1476-1482.


Chakraborty, T.R., Tkalych, O., Nanno, D., Garcia, A.L., Devi, L.A., Salton, S.R.J. (2006).  Quantification of VGF- and pro-SAAS-derived peptides in endocrine tissues and the brain, and their regulation by diet and cold stress.  Brain Research 1089:21-32.


Pan, H., Nanno, D., Che, F.Y., Zhu, X.R., Salton, S.R., Steiner, D.F., Fricker, L.D., Devi, L.A. (2005).  Neuropeptide processing profile in mice lacking prohormone convertase-1.  Biochemistry 44:4939-48.

Watson, E., Hahm, S., Mizuno, T.M., Windsor, J., Montgomery, C., Scherer, P.E., Mobbs, C.V., Salton, S. (2005) VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 146:5151-63.

Garcia, A.L., Han, S.K., Janssen, W.G., Khaing, Z.Z., Ito, T., Glucksman, M.J., Benson, D.L., Salton, S.R. (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem 280:41595-608.


Levi, A., Ferri, G.L., Watson, E., Possenti, R., Salton, S.R.J. (2004).  Processing, distribution and function of VGF, a neuronal and endocrine peptide precursor.  Cell. Molec. Neurobiol. 24:517-533.

Mobbs, C., Yen, K., Mastaitis, J., Nguyen, H., Watson, E., Wurmbach, E., Sealfon, S.C., Brooks, A., Salton, S.R.J. (2004).  Mining microarrays for metabolic meaning:  nutritional regulation of hypothalamic gene expression.  Neurochem. Res. 29:1093-1103.


Mintz, C.D., Dickson, T.C., Gripp, M.L., Salton, S.R.J., Benson, D.L. (2003).  ERMs colocalize transiently with L1 during neocortical axon outgrowth.  J. Comp. Neurol. 464:438-448.

Snyder, S.E., Peng, B, Pintar, J.E., Salton S.R.J. (2003).  Expression of VGF mRNA in developing neuroendocrine and endocrine tissues.  J. Endocrinol. 179:227-235.


Hahm, S., Fekete, C., Mizuno, T.M., Windsor, J., Yan, H., Boozer, C.N., Lee, C., Elmquist, J.K., Lechan, R.M., Mobbs, C.V., Salton, S.R. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment and agouti, and is differentially regulated in POMC- and NPY-containing arcuate neurons in response to fasting. J Neurosci 22:6929-6938.
Dickson, T.C., Mintz, C.D., Benson, D.L., Salton, S.R. (2002) Functional binding interaction identified between the axonal CAM L1 and members of the ERM family. J Cell Biol 157:1105-12.


Eagleson K.L., Fairfull, L.D., Salton S.R.J., Levitt P, (2001).  Regional differences in neurotrophin availability regulate selective expression of VGF in developing limbic cortex.  J. Neurosci. 21:9315-9324.


Salton, S.R.J., Hahm, S., Mizuno, T.M. (2000).  Of Mice and MEN:  what transgenic models tell us about hypothalmic control of energy balance.  Neuron 25:265-268.

Salton, S.R.J., Ferri, G.L., Hahm, S., Snyder, S.E., Wilson, A.J., Possenti, R., Levi, A. (2000).  VGF:  a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance. Frontiers in Neuroendocrinology, 21:199-219.


Hahm, S., Mizuno, T.M., Wu, T.J., Wisor, J.P., Priest, C.A., Kozak, C.A., Boozer, C.N., Peng, B., McEvoy, R.C., Good, P., Kelley, K.A., Takahashi, J.S., Pintar, J.E., Roberts, J.L., Mobbs, C.V., Salton, S.R. (1999) Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron 23:537-48.

Salton Laboratory
Lab Location: CSM9-301-SL
Office Location: CSM9-110

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Mount Sinai School of Medicine
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