neuro
slesinger lab
laboratory of membrane excitability & disease

Selected Publications

2016

A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAB receptor-activated GIRK currents in VTA dopamine neurons. Munoz MB, Padgett CL, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ and Slesinger PA. (2016) J. Neurosci (in press)

Construction of cell-based neurotransmitter fluorescently engineered reporters (CNiFERs) for optical detection of neurotransmitters in vivo Lacin M, Muller A, Kleinfeld D and Slesinger, PA (2016) Construction of cell-based neurotransmitter fluorescently engineered reporters (CNiFERs) for optical detection of neurotransmitters in vivo. Journal of Visualized Experiments (in press).

2015

Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens. Khibnik LA, Beaumont M, Doyle M, Heshmati M, Slesinger PA, Nestler EJ, Russo SJ. Biol Psychiatry. 2015 Jun 6. pii: S0006-3223(15)00471-0. doi:

GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol. Herman MA, Sidhu H, Stouffer DG, Kreifeldt M, Le D, Cates-Gatto C, Munoz MB, Roberts AJ, Parsons LH, Roberto M, Wickman K, Slesinger PA, Contet C. Proc Natl Acad Sci USA. 2015 Jun 2;112(22):7091-6. doi: 10.1073/pnas.1416146112.

GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner. Kotecki L, Hearing M, McCall NM, Marron Fernandez de Velasco E, Pravetoni M, Arora D, Victoria NC, Munoz MB, Xia Z, Slesinger PA, Weaver CD, Wickman K. J Neurosci. 2015 May 6;35(18):7131-42. doi: 10.1523/JNEUROSCI.5051-14.2015.

Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. Liu J, Magri L, Zhang F, Marsh NO, Albrecht S, Huynh JL, Kaur J, Kuhlmann T, Zhang W, Slesinger PA, Casaccia P. J Neurosci. 2015 Jan 7;35(1):352-65. doi: 10.1523/JNEUROSCI.2606-14.2015.

Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor. Huynh TG, Cuny H, Slesinger PA, Adams DJ. Mol Pharmacol. 2015 Feb;87(2):240-50. doi: 10.1124/mol.114.096156

2014

Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex. Muller A, Joseph V, Slesinger PA, Kleinfeld D. Nat Methods. 2014 Dec;11(12):1245-52. doi: 10.1038/nmeth.3151. Epub 2014 Oct 26.

Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response. Munoz MB, Slesinger PA. Neuron. 2014 May 7;82(3):659-69. doi: 10.1016/j.neuron.2014.03.011.

Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity. Lalive AL, Munoz MB, Bellone C, Slesinger PA, Lüscher C, Tan KR. J Neurosci. 2014 Apr 9;34(15):5107-14. doi: 10.1523/JNEUROSCI.5203-13.2014.

2013

Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels. Bodhinathan K, Slesinger PA. Proc Natl Acad Sci USA. 2013 Nov 5;110(45):18309-14. doi: 10.1073/pnas.1311406110.

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. Balana B, Bahima L, Bodhinathan K, Taura JJ, Taylor NM, Nettleton MY, Ciruela F, Slesinger PA. PLoS One. 2013;8(3):e59800. doi: 10.1371/journal.pone.0059800.

2012

Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Padgett CL, Lalive AL, Tan KR, Terunuma M, Munoz MB, Pangalos MN, Martínez-Hernández J, Watanabe M, Moss SJ, Luján R, Lüscher C, Slesinger PA. Neuron. 2012 Mar 8;73(5):978-89. doi: 10.1016/j.neuron.2011.12.031.

2011

Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. Laviv T, Vertkin I, Berdichevsky Y, Fogel H, Riven I, Bettler B, Slesinger PA, Slutsky I. J Neurosci. 2011 Aug 31;31(35):12523-32. doi: 10.1523/JNEUROSCI.1527-11.2011.

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Balana B, Maslennikov I, Kwiatkowski W, Stern KM, Bahima L, Choe S, Slesinger PA. Proc Natl Acad Sci USA. 2011 Apr 5;108(14):5831-6. doi: 10.1073/pnas.1018645108.

2009

A discrete alcohol pocket involved in GIRK channel activation. Aryal P, Dvir H, Choe S, Slesinger PA. Nat Neurosci. 2009 Aug;12(8):988-95. doi: 10.1038/nn.2358. Epub 2009 Jun 28.

2007

RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Labouèbe G, Lomazzi M, Cruz HG, Creton C, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K, Boyer SB, Slesinger PA, Lüscher C. Nat Neurosci. 2007 Dec;10(12):1559-68. Epub 2007 Oct 28.