Moore Lab - Research

Welcome to the Moore Laboratory
for Integrative Stem Cell Biology

Kateri Moore

   My research is focused on defining the cellular and molecular nature of hematopoietic stem cells (HSCs) and the molecular cross-talk that occurs between stem cells and their niche. We use transgenic mouse models to study HSC during normal homeostasis and after stress. We are interested in the basic property of self-renewal and whether HSCs really do self-renew to full functional potential when they undergo cell division. The lab is also using specific factors to directly induce hemogenesis from somatic cells, both mouse and human. We have shown that the induction process recapitulates developmental hematopoies and molecular cues from these studies have led to a new investigation of HSC precursor populations during embryonic development. Overall our studies will have broad implications on the behavior of all stem cells including those that contribute to metastatic cancer and leukemias. 

Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells. Pereria et al.

lab info

Ihor R. Lemischka (1953–2017)

“Ihor loved science and life, and to him they were two sides of the
same coin. As a graduate student, he cloned genes and was fascinated by pseudo-genes. As a mature scientist, he plumbed the depths of hematopoietic stem cells and development, producing papers with massive data and insights. He left us much too soon.” –
Phillip Sharp, Ph.D.,
Nobel Laureate, MIT
... read more here

Kateri Moore

212-659-8312 (office)
212-659-8228 (office)
212-659-8283 (lab)
212-803-6740 (fax)

lab members:
graduate student:
Bernitz, Jeffrey
Daniel, Michael
Katz, Suzanna
Kim, Huen Suk
Lau, Kwun Kit
Yuan, Ye (James)

stem cell core:
D'Souza, Sunita
Alexeeva, Vera
Ayudin, Iraz

see photos and more here.
key publications

Bernitz JM, Kim HS, MacArthur B, Sieburg H, Moore K.,
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
Cell. 2016 Nov 17;167(5):1296-1309.e10. doi: 10.1016/j.cell.2016.10.022. PubMed PMID: 27839867.
Commented in Dev Cell. 2016 Nov 21;39(4):390-391. doi: 10.1016/j.devcel.2016.11.005.
Fast EM1, Ira Zon L2.
Aging Hematopoietic Stem Cells Make Their History.

Pereira CF, Chang B, Gomes A, Bernitz J, Papatsenko D, Niu X, Swiers G, Azzoni E, de Bruijn MF, Schaniel C, Lemischka IR, Moore KA.,
Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells. 
Developmental Cell. ; 36(5):525-39,
Developmental Cell Previews:
Tracking HSC Origin: From Bench to Placenta, V. Calvanese and H.K.A. Mikkola, Dev Cell, 

Brosh R, Hrynyk I, Shen J, Waghray A, Zheng N, Lemischka IR.,
A dual molecular analogue tuner for dissecting protein function in mammalian cells. 
Nat Commun. 2016 May 27;7:11742. doi: 10.1038/ncomms11742. 
PubMed PMID: 27230261
Central PMCID: PMC4895048.

Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R, Hung MC, Schaniel C, Lemischka IR.,
Modeling familial cancer with induced pluripotent stem cells.
Cell. 2015 Apr 9;161(2):240-54. doi: 10.1016/j.cell.2015.02.045.
PMID: 25860607 

see more publications here.