The VTA-NAc pathway is part of a series of parallel, integrated circuits, which also involve several other key brain regions.

The VTA is the site of dopaminergic neurons, which tell the organism whether an environmental stimulus (natural reward, drug of abuse, stress) is rewarding or aversive.

The NAc, also called ventral striatum, is a principal target of VTA dopamine neurons. This region mediates the rewarding effects of natural rewards and drugs of abuse.

The amygdala is particularly important for conditioned forms of learning. It helps an organism establish associations between environmental cues and whether or not that particular experience was rewarding or aversive, for example, remembering what accompanied finding food or fleeing a predator. It also interacts with the VTA-NAc pathway to determine the rewarding or aversive value of an environmental stimulus (natural reward, drug of abuse, stress).

The hippocampus is critical for declarative memory, the memory of persons, places, or things. Along with the amygdala, it establishes memories of drug experiences which are important mediators of relapse.

The hypothalamus is important for coordinating an individual's interest in rewards with the body's physiological state. This region integrates brain function with the physiological needs of the organism.

Probably the most important, but least understood, are prefrontal regions of cerebral cortex, such as medial prefrontal cortex, anterior cingulate cortex, and orbitofrontal cortex, which provide executive control over choices made in the environment (for example, whether to seek a reward). Several areas of preforntal cortex influence addiction in distinct ways.

The locus coeruleus is the primary site of noradrenergic neurons in the brain, which pervasively modulate brain function to regulate the state of activation and mood of the organism.

The dorsal raphe is the primary site of serotonergic neurons in the brain, which, like noradrenergic neurons, pervasively modulate brain function to regulate the state of activation and mood of the organism.

Of course, these various brain regions, and many more, do not function separately. Rather, they function in a highly inter-related manner and mediate an individual's responses to a range of environmental stimuli.

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