Recent Publications of the Program Project Grant

Recent Reviews:

Grueter, B.A., Robison, A.J., Neve, R.L., Nestler, E.J., and Malenka, R.C. (2013) ΔFosB differentially modulates nucleus accumbens direct and indirect pathway function. Proc. Natl. Acad. Sci. USA 110:1923-1928.

Dietz, D.M., Sun, H.S., Lobo, M.K., Cahill, M.E., Chadwick, B., Gao, V., Koo, J.W., Mazei-Robison, M.S., Dias, C., Maze, I., Damez-Werno, D., Dietz, K.C., Scobie, K.N., Ferguson, D., Christofell, D., Ohnishi, Y., Hodes, G.E., Zheng, Y., Neve, R.L., Hahn, K.M., Russo, S.J., and Nestler, E.J. (2012) Essential for Rac1 in cocaine-induced structure plasticity of nucleus accumbens neurons. Nature Neurosci. 15:891-896.

Koo, J.W., Mazei-Robison, M.S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H.S., Scobie, K.N., Damez-Werno, D., Crumiller, M., Ohnishi, Y.N., Ohnishi, Y.H., Mouzon, E., Dietz, D.M., Lobo, M.K., Neve, R.L., Russo, S.J., Han, M.H., and Nestler, E.J. (2012) BDNF is a negative modulator of morphine action. Science 338:124-128.

Robison, A.J. and Nestler, E.J. (2011) Transcriptional and epigenetic mechanisms of addiction. Nature Rev. Neurosci. 12:623-637.

Lüscher C, Malenka RC (2011) Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron 69:650-663.

Nestler, E.J. (2011) Hidden switches in the mind. Sci. Am., Dec. 2011, pp. 76-83.

Graham DL, Self DW (2010) Integrating Behavioral and Molecular Approaches in Mouse: Self-Administration Studies. In: Kuhn CM, Koob GF, editors. Advances in the Neuroscience of Addiction. 2nd edition. Boca Raton (FL): CRC Press; 2010. Chapter 5.

Kreitzer AC, Malenka RC (2008) Striatal plasticity and basal ganglia circuit function. Neuron 60:543-554.

Carlezon WA Jr, Chartoff EH (2007) Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc 2:2987-2995.


Recent Original Research Articles:

Taniguchi M, Carreira MB, Smith LN, Zirlin BC, Neve RL, Cowan CW (2012) Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron 73:108-20.

Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ (2011) Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci USA 108:3035-3040.

Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW (2011) Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. J Neurosci 31:7927-7937.

Covington HE, Maze I, Sun HS, Wu EY, Dietz D, Lobo MK, Ghose S, Neve R, Tamminga CA, Nestler EJ (2011) A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 71:656-670.

Larson EB, Graham DL, Arzaga RR, Buzin N, Webb J, Green TA, Bass CE, Neve RL, Terwilliger EF, Nestler EJ, Self DW (2011) Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. J. Neurosci. 31:16447-16457.

Muschamp JW, Van't Veer A, Parsegian A, Gallo MS, Chen M, Neve RL, Meloni EG, Carlezon WA Jr (2011) Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats. J Neurosci 31:3095-3103.

Lammel S, Ion DI, Roeper J, Malenka RC (2011) Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70:855-862.

Maze I, Covington HE III, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren YH, Sampath SC, Hurd YL, Greengard P, Tarakovsky A, Schaefer A, Nestler EJ (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327:213-216.

Grueter BA, Brasnjo G, Malenka RC (2010) Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens. Nat Neurosci 13:1519-1525.

Larson EB, Akkentli F, Edwards S, Graham DL, Simmons DL, Alibhai IN, Nestler EJ, Self DW (2010) Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. J Neurochem 115:112-122.

Citri A, Bhattacharyya S, Ma C, Morishita W, Fang S, Rizo J, Malenka RC (2010) Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci 30:16437-16452.

LaPlant, Q., Vialou, V., Covington, H.E., Dumitriu, D., Feng, J., Warren, B., Maze, I., Dietz, D.M., Watts, E.L., Iñiquez, S.D., Koo, J.-W., Mouzon, E., Renthal, W., Hollis, F., Wang, H., Noonan, M.A., Ren, Y.H., Eisch, A.J., Bolaños, C.A., Kabbaj, M., Xiao, G.H., Neve, R.L., Hurd, Y.L., Oosting, R.S., Fan, G.P., Morrison, J.H., and Nestler, E.J. (2010) Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neurosci. 13:1137-1143.

Cao JL, Vialou VF, Lobo MK, Robison AJ, Neve RL, Cooper DC, Nestler EJ, Han MH (2010) Essential role of the cAMP-CREB pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. Proc Natl Acad Sci USA 107:17011-17016.

Lobo MK, Covington HE III, Chaudhury D, Friedman AK, Sun HS, Damez-Werno D, Dietz D, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ (2010) Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390.

Winstanley CA, Bachtell RK, Theobald DEH, Laali S, Green TA, Kumar A, Chakravarty S, Self DW, Nestler EJ (2009) Increased impulsivity during withdrawal from cocaine self-administration: Role for ΔFosB in the orbitofrontal cortex. Cerebral Cortex 19:435-444.

Edwards S, Graham DL, Whisler KN, Self DW (2009) Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration. Synapse 63:224-235.

Renthal W, Kumar A, Xiao GH, Wilkinson M, Convington HE III, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ (2009) Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins. Neuron 62:335-348.

Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Berton O, Bolaños CA, DiLeone RJ, Parada LF, Nestler EJ, Self DW (2009) TrkB in the mesolimbic dopamine system: Region-specific effects on cocaine reward. Biol Psychiatry 65:696-701.

Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao GH, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW (2008) Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59:621-633.

Argilli E, Sibley DR, Malenka RC, England PM, Bonci A (2008) Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci 28:9092-9100.

Luu P, Malenka RC (2008) Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC. J Neurophysiol 100:533-538.

Bachtell RK, Self DW (2008) Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior. J Neurosci 28:12808-12814.

Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW (2007) Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci 10:1029-1037.

Renthal W, Maze I, Krishnan V, Covington HE, Xiao GH, Kumar A, Russo SJ, Graham A, Tsankova N, Kerstetter KA, Kippin TE, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56:517-529.



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